Sprint Interval Training on the Endurance, Strength and Velocity Capacities of Healthy Sedentary Subjects

Sedentary Behavior Clinical Trial

— BénéfiSIT  

Official title:

Sprint Interval Training (SIT) on the Endurance, Strength and Velocity Capacities of Healthy Sedentary Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05013021
• Other study ID #: 20CH238
• Secondary ID: ANSM
• Status: Completed
• Phase: N/A
• Start date: September 27, 2021
• Est. completion date: March 29, 2023

Study information

• Verified date: June 2022
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study aims to analyse first, the acute effects generated by a single bout of Sprint Interval Training (SIT) and, secondly, the effects of a long-term intervention on sedentary participants.

Description:

The main goal is to determine the optimal dose of high-intensity exercise that enhances the best physiological adaptations. The cumulative effects of SIT, will be assessed by a series of measures placed throughout the time-course (before, after the 1st , the 2nd and the 3rd block of SIT). Those measures consist of physiological measurements (VO2max), neuromuscular capacities (force-velocity profile) the autonomic nervous system responses (heart rate variability) and blood markers (lactate, Creatine phosphoKinase (CK), cytokinases, µRNA). Acute effects will be measured in the familiarisation sessions (after short (8 sprints) and long (14 sprints) sets) by performing a battery of neuromuscular, perceptual, and autonomic nervous system tests before and after the single session of SIT.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 23
• Est. completion date: March 29, 2023
• Est. primary completion date: March 8, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• untrained healthy (less than 2 hours of sport per week)
• free from muscular, bone or joint injuries
• free from neurologic disease

Exclusion Criteria:

• taking neuroactive substances that can alter corticospinal excitability
• Heart or respiratory failure.
• Subjects who have taken corticosteroids within 3 months (inhalation, infiltration or history of corticosteroid therapy).
• Pregnant woman
• Subject under guardianship

Related Conditions & MeSH terms

• Sedentary Behavior

Intervention

Other:
• Sprint Interval Training
The Sprint Interval Training (SIT) training consists of 3 successive blocks of 5 training sessions each. The sessions are 24 to 48 hours apart. . One block lasts two weeks. After the end of one block, the following block begins the day after. The Sprint Interval Training lasts 6 weeks. Each session consists of a series of sprints, the number of which varies from 8 to 14. Thus a session will last from 30 to 45 min approximately So, the time frame of this study is Baseline, Block 1, Block 2 and Block 3 (Not in day or week or month)

Locations

Country	Name	City	State
France	CHU de Saint-Etienne	Saint-Étienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	oxygen uptake (VO2max) - ml/min/kg	consumption oxygen uptake (VO2max) measured on a cycle ergometer; The main objective is to determine at which time frame of sprint interval training blocks, the endurance performance (VO2max) is best.	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	Maximum power (W)	It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively.	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	Maximum theoretical force (N.m)	It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively.	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	Maximum theoretical speed (m/s)	It is measured thanks to the force-speed profile using two sprints of 7s with braking forces of 0 , 4 and 0.7 N.kg-1 respectively.	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	Maximum isometric force (N.m)	It is measured by means of a voluntary maximum contraction test in which the maximum force generated voluntarily is compared to that voluntarily generated force will be compared to that evoked using electrical stimulation of the femoral nerve.	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	heart rate variability (HRV)		At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	Lactate (mmol/l)	Blood sample	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	Cytokines (pg/ml)	Blood sample	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	Creatine Kinase (UI/l)	Blood sample	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart
Secondary	muscle microRNA	Blood sample	At the end of the 1st, 2nd and 3rd block : Each block = 2 weeks; each block is 1 day apart