Vasopressor Requirements Depends on Sedation Strategy

Status Completed

Clinical Trial Summary

Most of the patients after cardiac surgery need sedation in the iCU. Sedation strategy could impact the incidence of vasopressor use.

Clinical Trial Description

Sedating a patient is a complex process, especially after heart surgery. Sedation has a negative hemodynamic effect. This leads to a decrease in blood pressure and increases the frequency and dose of vasopressors used. The choice of drug for sedation may have an impact on reducing the frequency of use of vasopressor therapy. The goal of the research is compare three strategies: propofol ( sedative agent), dexmedetomidine ( selective α2-adrenergic receptor (α2-AR) agonist that is associated with sedative effect) and their combination for sedation after cardiac surgery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05451381
Study type	Interventional
Source	Anesthesia Research Group UA
Contact
Status	Completed
Phase	N/A
Start date	August 1, 2017
Completion date	May 29, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03653910` - Effect-site Concentration of Remifentanil for Double-lumen Tubes Intubation: Airtraq VS Macintosh Laryngoscope	N/A
Completed	`NCT06000098` - Consol Time and Acute Kidney Injury in Robotic-assisted Prostatectomy
Recruiting	`NCT02565251` - Volemic Resuscitation in Sepsis and Septic Shock	N/A
Terminated	`NCT02365688` - Hemodynamic Response During Goal Directed Fluid Therapy in the OR	N/A
Completed	`NCT01605279` - Dobutamine Versus Placebo for Low Superior Vena Cava Flow in Newborns	Phase 2
Completed	`NCT01559675` - Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery	N/A
Recruiting	`NCT04010058` - Postoperative Continuous Non-invasive Haemodynamic Monitoring on the Ward	N/A
Completed	`NCT06268275` - Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy	N/A
Recruiting	`NCT04926220` - Dynamic Estimation of Cardiac Output in the Operating Room
Not yet recruiting	`NCT05003011` - Correlation of Hemodynamics Via Pulmonary Artery Catherization and the Cardiospire
Completed	`NCT03599440` - Effect of Extended Infusion Lines on Pulse Contour-based Measurements
Completed	`NCT05035485` - Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia	N/A
Not yet recruiting	`NCT04227821` - Hemodynamic Optimalization in Pediatric Patients
Completed	`NCT05481047` - Prevention or Treatment of Arterial Hypotension and Oxygen Cerebral Saturation During Major Abdominal Surgery	N/A
Completed	`NCT06158165` - Evaluating The Cardiovascular Effects of Tourniquet Application
Not yet recruiting	`NCT04076709` - Cardiovascular Effects of Muscle Relaxation During Laparoscopic Surgery	Phase 4
Completed	`NCT04089098` - VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
Not yet recruiting	`NCT03828032` - Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.	N/A
Recruiting	`NCT05570682` - Manually Controlled Infusion vs Target Controlled Infusion for StrokeThrombectomy	N/A
Completed	`NCT04574908` - A Pilot Trial of Continuous Portable Postoperative Hemodynamic And Saturation Monitoring On Hospital Wards	N/A