Second Trimester Abortion Clinical Trial
Official title:
Measuring Response of Adding Isosorbide Mononitrate to Misoprostol in Induction of Second Trimester Abortion
Verified date | February 2018 |
Source | Ain Shams University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
the investigators aimed to study the efficacy and safety of nitric oxide donors when combined
with prostaglandins in induction of second trimester abortion expecting that both drugs when
used together will be of greater efficiency and associated with less side effects.
the study included 60 women with gestational age between 13weeks+0day and 26weeks+6days
indicated for pregnancy termination due to maternal or fetal cause.
Status | Completed |
Enrollment | 60 |
Est. completion date | December 15, 2017 |
Est. primary completion date | October 22, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 16 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Age 16 -40 years - Missed abortion - Singelton pregnancy - Gestationl age between 13 and 26 weeks of pregnancy - Normal uterus and cevix on clinical examination - Cervix is not dilatated - No uterine activity and vaginal bleeding - Written and informed consent by the patient - Unscarred uterus Exclusion Criteria: - Presence of uterine contraction or bleeding - Evidences suggesting of onset of spontaneous abortion as Previous trial to induce abortion - Multifetal pregnancy - Suspicion of septic abortion - History of cervical surgery or manipulation - Uterine anomaly - IUD in situ - Associtaed hemorrhagic disorder - History of adverse effects to vaginally adminstered medication - Inability to insert vaginal medication high in vagina |
Country | Name | City | State |
---|---|---|---|
Egypt | Faculty of Medicine Ain Shams University | Cairo |
Lead Sponsor | Collaborator |
---|---|
Ain Shams University |
Egypt,
Jain JK, Mishell DR Jr. A comparison of misoprostol with and without laminaria tents for induction of second-trimester abortion. Am J Obstet Gynecol. 1996 Jul;175(1):173-7. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | induction abortion interval | time needed to induce abortion in second trimester abortion | 24 hours |
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