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Clinical Trial Summary

the investigators aimed to study the efficacy and safety of nitric oxide donors when combined with prostaglandins in induction of second trimester abortion expecting that both drugs when used together will be of greater efficiency and associated with less side effects.

the study included 60 women with gestational age between 13weeks+0day and 26weeks+6days indicated for pregnancy termination due to maternal or fetal cause.


Clinical Trial Description

the study aimed to compare the effect of isosorbid mononitrate when combined with misoprostol and misoprostol when used alone in second trimester abortion, expecting that both drugs when used together will be more effective and associated with fewer side effects.

In this study 60 women were enrolled, divided into two groups. The first group (group I), 30 women received misoprostol and isosorbid mononitrate.

The second group (group II), 30 women received misoprostol and placebo. The primary aim of the study was the occurrence of complete abortion in the first 24 hours.

The study concluded that the combination of isosorbid mononitrate with misoprostol is more effective in second trimester abortion than misoprostol with placebo, but is associated with more side effects mainly headache. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03407521
Study type Interventional
Source Ain Shams University
Contact
Status Completed
Phase Phase 4
Start date April 12, 2017
Completion date December 15, 2017

See also
  Status Clinical Trial Phase
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Recruiting NCT04501809 - Second Trimester Pregnancy Termination in Women With Previous Caesarean Sections N/A
Recruiting NCT03044093 - Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion Phase 4
Enrolling by invitation NCT06078501 - MisOpRostol Effect on Second Trimester Abortion Blood Loss Phase 3
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Completed NCT06164067 - The Role of Cervical Consistency Index and Uterocervical Angles in Medical Termination
Completed NCT02033083 - Laminaria Compared to Dilapan-S for Cervical Preparation Before Dilation and Evacuation at 18-24 Weeks of Gestation N/A
Recruiting NCT06123026 - Pharmacological Inhibition of Lactation After 16 to 20 Week Abortion Phase 4
Terminated NCT03714880 - Cervical Preparation With Mifepristone Prior to Osmotic Dilators Phase 2