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Second Trimester Abortion clinical trials

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NCT ID: NCT06164067 Completed - Clinical trials for Second Trimester Abortion

The Role of Cervical Consistency Index and Uterocervical Angles in Medical Termination

Start date: February 15, 2022
Phase:
Study type: Observational [Patient Registry]

The main aim of the investigator study is the success of predictivity cervical consistency index (CCI), anterior uterocervical angle (aUCA) and posterior uterocervical angle (pUCA) in second trimester terminations.

NCT ID: NCT06123026 Recruiting - Clinical trials for Second Trimester Abortion

Pharmacological Inhibition of Lactation After 16 to 20 Week Abortion

Start date: December 18, 2023
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to compare breast symptoms (lactation, engorgement, etc) of individuals who undergo a procedure for second trimester of pregnancy loss between 16 weeks and 20 weeks gestational age. The participants will be randomly placed in two groups, one with a placebo tablet and one with medication called "cabergoline" which are taken immediately after their procedure. Researchers will compare groups to see if there are any significant differences in breast symptoms.

NCT ID: NCT06078501 Enrolling by invitation - Clinical trials for Blood Loss, Surgical

MisOpRostol Effect on Second Trimester Abortion Blood Loss

MORESTABL
Start date: February 8, 2024
Phase: Phase 3
Study type: Interventional

Although serious complications from second trimester abortion are rare hemorrhage is the most common cause of procedural abortion related morbidity and mortality. Misoprostol is a prostaglandin E1 analogue that is used by 75% of clinicians prior to procedural abortion for the purpose of cervical preparation. Misoprostol is also known to decrease blood loss in first trimester abortion and is used to treat postpartum hemorrhage, however the effect of preprocedural misoprostol on procedural blood loss is not well described. We will conduct a double blinded placebo-controlled gestational age stratified superiority trial of those undergoing procedural abortion between 18 and 23 weeks gestation at Stanford Health care. Participants will be randomized to either 400mcg buccal misoprostol or placebo on the day of the procedure. A quantified blood loss (QBL) will be measured during the procedure and participants will complete a survey to assess symptoms. Our primary outcome is quantified blood loss. Secondary outcomes include clinical interventions to manage excess bleeding, total procedure time, provider reported experience, patient reported experience.

NCT ID: NCT04501809 Recruiting - Clinical trials for Second Trimester Abortion

Second Trimester Pregnancy Termination in Women With Previous Caesarean Sections

Start date: July 15, 2020
Phase: N/A
Study type: Interventional

it is a randomized controlled trial comparing the safety and efficacy of Vaginal Misoprostol versus combined Intracervical Foley's Catheter and Oxytocin Infusion for Second Trimester Pregnancy Termination. the patients will be sorted into 2 groups, Group I (Misoprostol group): seventy-nine patients and Group II (Combined group): seventy- nine patients. safety and efficacy of the procedure will be followed up and documented.

NCT ID: NCT04181541 Completed - Medical Abortion Clinical Trials

Midlevel Versus Physician-provided Medical Abortion in the Second Trimester

Start date: February 17, 2020
Phase: N/A
Study type: Interventional

The purpose of the study is to determine the safety and effectiveness of second trimester medical abortion when provided by nurse midwives compared with physicians. The study sample will be obtained from Michu Clinic, affiliated with St Paul's hospital, in Addis Ababa.

NCT ID: NCT04063904 Terminated - Clinical trials for Second Trimester Abortion

Pilot Study of an Ambulatory Medical Abortion Service at 13-18 Weeks of Gestation in Colombia

Start date: October 16, 2019
Phase: Phase 4
Study type: Interventional

This pilot study seeks to evaluate the safety, acceptability and feasibility of a shortened outpatient procedure for medical abortion at 13-18 weeks gestation. It also seeks to document the roles of health workers in providing services related to later abortion care. Participants will take a single dose of 200 mg mifepristone orally, followed 24-48 hours later with 400 mcg misoprostol sublingually prior to arriving at the study clinic. Repeat doses of 400 mcg misoprostol will be administered sublingually every three hours at the clinic until the abortion is achieved. If expulsion does not occur by a certain time prior to the clinic closing that day, D&E will be performed to complete the abortion.

NCT ID: NCT03714880 Terminated - Clinical trials for Second Trimester Abortion

Cervical Preparation With Mifepristone Prior to Osmotic Dilators

Start date: April 26, 2019
Phase: Phase 2
Study type: Interventional

The investigators plan to study the role of mifepristone prior to the placement of cervical osmotic dilators to evaluate if the medication helps increase the number of dilators. This may help improve safety of dilation and evacuation (D&E) procedures.

NCT ID: NCT03407521 Completed - Clinical trials for Second Trimester Abortion

Misoprosotol and Isosorbide Mononitrate for Induction of Second Trimester Abortion

Start date: April 12, 2017
Phase: Phase 4
Study type: Interventional

the investigators aimed to study the efficacy and safety of nitric oxide donors when combined with prostaglandins in induction of second trimester abortion expecting that both drugs when used together will be of greater efficiency and associated with less side effects. the study included 60 women with gestational age between 13weeks+0day and 26weeks+6days indicated for pregnancy termination due to maternal or fetal cause.

NCT ID: NCT03400358 Completed - Clinical trials for Medical; Abortion, Fetus

Uterocervical Angle in the Pregnancy Termination of Multiparous Women

Start date: October 1, 2017
Phase: N/A
Study type: Observational

To evaluate the uterocervical angle (UCA) in the prediction of second trimester termination success of multiparous women.

NCT ID: NCT03044093 Recruiting - Clinical trials for Second Trimester Abortion

Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion

Start date: January 2017
Phase: Phase 4
Study type: Interventional

Mifepristone and Misoprostol Compared With Misoprostol Alone for Second Trimester Abortion - a Double Blinded Randomized Controlled Trial