Second- or Third-degree Burns Clinical Trial
Official title:
Safety and Efficacy Evaluation of Tissue Engineered Construct Based on Allogeneic Adipose-derived Multipotent Mesenchymal Stromal Cells and Platelet-poor Plasma Fibrin Hydrogel to Treat the Patients With Burn Wounds
The purpose of this study is to evaluate safety and efficacy of tissue engineered construct based on allogeneic cultured adipose-derived multipotent mesenchymal stromal cells (ALLO-ADSCs) and platelet-poor plasma fibrin hydrogel to treat patients with 2-B and 3- degree burn wounds
For more than 20 years in clinical practice allogeneic transplantation of diploid
fibroblasts (ADP) for burn wounds has been successfully used, it is used as an independent
method, and a method of preparing wounds for autologous skin grafting [1].
The clinical efficacy of transplantation ADP, after the research done by E.V. Glushchenko;
Rahayev AM [2,3] is not doubted.
Several studies have shown the efficacy of stem cells in promoting faster and superior wound
healing. Alexaki [4] successfully used adipose derived mesenchymal stem cells in wound
healing in mice and compared their effect with dermal fibroblasts. The application of stem
cells in wounds promoted more efficient reepithelialization by their proliferative effect on
keratinocytes.
In recent years, the world's leading burn centers attempted to restore the skin over large
areas of burn wounds by epidermal layers transplantation of allogeneic cells cultured in
culture medium.
The information expected in the study will be based on the principles of evidence-based
medicine and will have practical significance for the treatment of burn wounds.
It is expected to show a positive effect of cultured multipotent mesenchymal stromal cells
in the epithelization of burn wounds process as well as the extent and speed healing of skin
flap during autologous skin grafting.
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