Second Degree Burns Clinical Trial
Official title:
Comparative Study of Conventional and Topical Heparin Treatments in Second Degree Burn Patients for Burn Analgesia and Duration of Wound Healing
Pain Associated with partial thickness burns (PTB) is very severe and distressing for the patients.Topical conventional treatment of superficial PTB wounds includes application of polyfax skin ointment plus lignocain gel twice a day after wound wash while deep PTB are treated with silvazine cream twice a day and prepared for grafting if not healed within 3 weeks. Existing conventional therapy is un-comfortable and expensive for the patients. Search continues for a reliable, safe, cheap and effective treatment of burn.Topical use of heparin has been found effective in reducing pain associated with burn wounds. More over use of heparin topically in burn patients is easy to perform and cheap but at the moment, evidence of its effectiveness is weak. Current study is being conducted to verify clinical effectiveness of use of heparin in 2nd degree burns by comparing it with topical conventional treatment.
Second degree or partial thickness burn (PTB) is most tricky variety to identify and treat,
out of all four categories of burn (based on depth). It is further divided into superficial
and deep partial thickness based on the depth of dermal injury. (1) Clinical criteria
fulfilling all the points for each category i.e. Superficial PTB (SPTB) being reddish pink,
bleed briskly (in <3sec) on pin prick, blanch with brisk return (in <2 sec) on pressure,
blister formation and Deep PTB (DPTB) being mottled pink, delayed bleeding (in >3 sec) on
pin prick, slow return (in >2 sec) on pressure, no blister, is most commonly used to
differentiate both the sub-classes. Pain is hallmark of 2nd degree burns and is treated by
topical and IV analgesics. Topical conventional treatment of superficial PTB wounds includes
application of polyfax skin ointment plus lignocain gel twice a day after wound wash while
deep PTB are treated with silvazine cream twice a day and prepared for grafting by normal
saline dressings, if not healed within 3 weeks.
Current treatment for 2nd degree burn is complex, uncomfortable for the patient and
expensive for the health systems (2,3) . Search continues for a reliable, safe, cheap and
effective treatment of burn. Heparin has been used topically in burn patient and a protocol
of topical heparin use has been introduced . It is believed that heparin helps in reducing
pain associated with burns and duration of wound healing. (4) It is noted that the mechanism
involved in heparin's action on the burn probably derives from its anti-inflammatory and
angiogenic properties, stimulating tissue repair and re-epithelializing effects.(2) These
actions do not depend on its well-known anticoagulant action. Burn analgesia by heparin is
caused by inhibition of pro-inflammatory products which act on free nerve endings and cause
pain. In this regard, isolated case reports continue to emerge, suggesting that heparin is
able to promote tissue repair and inhibit inflammation in burn patients.(5) It has been
shown in a study that out of total 58 patients, those in topical Heparin group demanded less
analgesic medications in mg/day (11.83 ± 9.38) than Control group (33.35± 20.63) . It has
been reported in another study that heparin applied topically for 5 days in 50 pediatric
patients reduced healing time. (6) Indeed there are a number of reports of heparin being
used, topically or systemically but there is a lack of effectively controlled studies in
this area for clear conclusions to be drawn as to the efficacy of this approach.(7) As it is
noted that already existing conventional therapy is un-comfortable and expensive for the
patients, use of heparin topically in burn patients is easy to perform and cheap but at the
moment, evidence of its effectiveness is weak. So rationale of the study is to verify
clinical effectiveness of use of heparin in 2nd degree burns.
Objective:- To compare conventional treatment and topical heparin treatment in 2nd degree
burn patients in terms of total consumption of analgesic medication and duration of wound
healing.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT01627769 -
Evaluation and Comparison of Keloids and Second Degree Burns Blisters Fluid
|
N/A |