DNA Vaccine for Ragweed Allergic Adults

Seasonal Allergic Rhinitis Clinical Trial

Official title:

A Phase II Observer-blind, Randomized, Placebo-Controlled Study of the Efficacy, Safety, Tolerability, and Immunogenicity of Subcutaneously Administered Dynavax Amb a 1 Immunostimulatory Oligodeoxyribonucleotide Conjugate (AIC) in Ragweed-Allergic Adults (Sponsor's Protocol NRH01)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00346086
• Other study ID #: AAC01-03-27-01
• Secondary ID: NRH01
• Status: Completed
• Phase: Phase 2
• Start date: May 18, 2001
• Est. completion date: August 21, 2001

Study information

• Verified date: December 2018
• Source: Johns Hopkins University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Various chemical modifications of allergens have been attempted to enhance efficacy, improve safety, and foster compliance with IT. These approaches have been unsuccessful - in that the allergenicity and immunogenicity have either decreased, or increased in tandem, with no resultant efficacy: safety benefit ratio. This study utilizes an adjuvant approach in which synthetic immunostimulatory DNA is conjugated to ragweed allergen in an attempt to modulate both the clinical and immunologic allergic response to ragweed exposure in ragweed-allergic patients with seasonal rhinitis.

Description:

Evaluation of efficacy and safety of allergen-CpG oligonucleotide immunostimulatory conjugate in treatment of ragweed-induced seasonal allergic rhinitis. Study incorporates clinical outcomes (symptom diaries, medication diaries, visual analog scores, quality of life questionnaires), safety measurements, immunologic assays (antibody measurements, T-cell assays, cytokine assays, nasal provocation).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: August 21, 2001
• Est. primary completion date: August 21, 2001
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Adult men and women 18 to 60 years of age;

• Who provide informed consent;

• Have a history of fall, seasonal, allergic rhinitis consistent with ragweed allergy;

• Exhibit a positive skin test to licensed , standardized, ragweed extract and a positive acute response to ragweed nasal challenge;

• Are in general good health; and are available for the duration of the study.

Exclusion Criteria:

• Individuals with medical conditions or taking medications that might interfere with interpretation of the study results will be excluded.

• Those with a history of severe symptoms of allergic rhinitis during the spring and summer grass pollen season will be excluded.

Related Conditions & MeSH terms

• Rhinitis
• Rhinitis, Allergic
• Rhinitis, Allergic, Seasonal
• Seasonal Allergic Rhinitis

Intervention

Drug:
• AIC (Amb a 1 Immunostimulatory Conjugate)

Locations

Country	Name	City	State
United States	Johns Hopkins University School of Medicine	Baltimore	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
Johns Hopkins University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effect of treatment on nasal allergen challenge