DNA Vaccine for Ragweed Allergic Adults

Status Completed

Clinical Trial Summary

Various chemical modifications of allergens have been attempted to enhance efficacy, improve safety, and foster compliance with IT. These approaches have been unsuccessful - in that the allergenicity and immunogenicity have either decreased, or increased in tandem, with no resultant efficacy: safety benefit ratio. This study utilizes an adjuvant approach in which synthetic immunostimulatory DNA is conjugated to ragweed allergen in an attempt to modulate both the clinical and immunologic allergic response to ragweed exposure in ragweed-allergic patients with seasonal rhinitis.

Clinical Trial Description

Evaluation of efficacy and safety of allergen-CpG oligonucleotide immunostimulatory conjugate in treatment of ragweed-induced seasonal allergic rhinitis. Study incorporates clinical outcomes (symptom diaries, medication diaries, visual analog scores, quality of life questionnaires), safety measurements, immunologic assays (antibody measurements, T-cell assays, cytokine assays, nasal provocation). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00346086
Study type	Interventional
Source	Johns Hopkins University
Contact
Status	Completed
Phase	Phase 2
Start date	May 18, 2001
Completion date	August 21, 2001

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT01337323` - Prospective Observational Study of Concomitant Allergic Rhinitis Treatment Patterns Among Patients Starting on Fluticasone Furoate Nasal Spray in a Retail Pharmacy Setting	N/A
Completed	`NCT01171664` - Clinical Trial of STAHIST in Seasonal Allergic Rhinitis (SAR) Subjects	Phase 2
Completed	`NCT00784732` - A Study to Compare the Efficacy of QAV680 Against Placebo in Treating Seasonal Allergic Rhinitis in an Environmental Exposure Chamber	Phase 2
Completed	`NCT00619827` - Efficacy and Safety of Sublingual Tablets of Grass Pollen Allergen Extract	Phase 1
Completed	`NCT00578929` - Safety and Efficacy of Olopatadine HCl Nasal Spray in 6-11 Year Old Patients	Phase 3
Completed	`NCT00209365` - The Role of Pollen Starch Granules in Pollen Challenge Studies in the Fraunhofer Environmental Exposure Unit	N/A
Terminated	`NCT00223587` - Seasonal Allergic Rhinitis and Driving Ability	Phase 4
Completed	`NCT00637455` - Single Center, Randomized, Double-Blind,Crossover Study Comparing Effects Of Single-Dose Fexofenadine HCl 180 mg, Cetirizine 10 mg, and Placebo on Cognitive Performance in Naval Flight Personnel	Phase 4
Completed	`NCT00963599` - Montelukast in Seasonal Allergic Rhinitis - Fall 1999 Study (0476A-117)	Phase 3
Recruiting	`NCT05346718` - Threshold Concentrations for Ragweed and Birch Pollen in Seasonal Allergic Rhinitis	N/A
Completed	`NCT06126952` - Azelastine Allergen Chamber - Onset of Action Study	Phase 2
Completed	`NCT01940146` - Efficacy and Safety of SPARC1310 in Seasonal Allergic Rhinitis	Phase 2
Completed	`NCT02245360` - Study Immunology and Safety of 60-day Treatment of SQ Grass SLIT (Sublingual Immunotherapy)-Tablet in Adult Subjects With Grass Pollen-induced Allergic Rhinoconjunctivitis	Phase 3
Completed	`NCT01230619` - Vienna Challenge Chamber Study Using RV658 in Subjects With Allergic Rhinitis	Phase 2
Completed	`NCT00574210` - PK/PD and Steady State Efficacy Study of Bilastine Compared With Placebo Given Orally in the Treatment of the Symptoms of SAR in an EEC Model (5-arm)	Phase 2
Completed	`NCT00561717` - A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis	Phase 4
Completed	`NCT00405899` - Pilot Study of Allergy Immunotherapy and Prevention of Viral Respiratory Infections	N/A
Completed	`NCT00443495` - Phase I/IIa Study on Chitin Microparticles in Subjects Suffering From Allergic Rhinitis	Phase 1/Phase 2
Completed	`NCT00420082` - A Randomized, Double-Blind, 4-way Crossover Study to Evaluate the Efficacy of Bilastine in the Vienna Challenge Chamber	Phase 2
Completed	`NCT03097432` - Non-interventional Study to Assess the Tolerability, the Safety Profile and the Adherence of Different Up-dosing Schemes for a Sublingual Immunotherapy Treatment	N/A