Assessment of the Level of Physical Dependence and Blockade Efficacy Produced by Tramadol
Opioids are one of the most commonly abused drugs among individuals who seek treatment for drug abuse. Thus, it is necessary to develop new treatments for opioid addiction. The purpose of this trial is determine whether tramadol is effective in treating opioid dependent individuals.
NCT00301210 — Opioid-Related Disorders
Status: Completed
http://inclinicaltrials.com/opioid-related-disorders/NCT00301210/
Linkage of Alcohol Abusers to Primary Care
The objective of this study is to test whether a chronic disease management (CDM) program for substance abusers in primary care leads to improved alcohol and drug-related outcomes (such as reduced consumption and health problems) and health care utilization patterns.
NCT00278447 — Alcoholism
Status: Completed
http://inclinicaltrials.com/alcoholism/NCT00278447/
Naltrexone Implants as an Aid in Preventing Relapse Following Inpatient Treatment for Opioid Addiction.
The purpose of this clinical trial is to study the efficacy and safety of naltrexone implants as relapse prevention for patients that are completing treatment for opiate addiction in inpatient (or similarly controlled) settings. Participants in the naltrexone experimental group are prematched in a pairwise fashion with other patients who do not want a naltrexone implant during the first six months after ending inpatient treatment, but who reiceive treatment as usual (TAU) from the Norwegian healthcare system. The hypotheses are that quality of life, depression, opioid use, will be significantly better in the naltrexone group compared to the non at 6-, 12-, and 18-month follow-up. We also hypothesize that the implants can prevent death from opioid overdose up to 6 months after commenced treatment.
NCT00269607 — Opioid Dependency
Status: Terminated
http://inclinicaltrials.com/opioid-dependency/NCT00269607/
Safety of Nicotine Reduction Strategy
This is a 2-year study involving the progressive reduction in the nicotine content of cigarettes. The investigators believe that at the end of the study smokers of cigarettes with progressively reduced nicotine content will be "weaned" from nicotine. At the end of the study, the result will be a decreased level of nicotine dependence. When smokers are again free to choose any smoking behavior, they will smoke fewer cigarettes and/or have a greater interest in quitting compared to a control group that smokes their usual cigarettes.
NCT00264342 — Nicotine Dependence
Status: Completed
http://inclinicaltrials.com/nicotine-dependence/NCT00264342/
Effectiveness of Contingency Management in VA Addictions Treatment
Contingency management interventions involve providing a tangible reward for progress toward treatment goals. The purpose of this study is to determine whether a contingency management intervention added to usual care leads to improved attendance and decreased substance use in patients attending outpatient substance use disorders treatment.
NCT00252512 — Substance Use Disorders
Status: Completed
http://inclinicaltrials.com/substance-use-disorders/NCT00252512/
Drug Treatment for Transplant Candidates
The purpose of this study is to test a novel distance-based (telephone) intervention to help transplant candidates with current or recent substance abuse to stay "clean and sober" both prior and following transplant surgery.
NCT00249652 — End Stage Renal Disease
Status: Completed
http://inclinicaltrials.com/end-stage-renal-disease/NCT00249652/
Evaluation of Dialectical Behavior Therapy in Treatment of Opioid Addiction and Emotional Problems
The purpose of this study is to examine the efficacy of DBT compared to a standard drug counseling approach for the treatment of opiate addiction and borderline personality disorder (BPD). Treatment research has repeatedly shown that retention of BPD and substance addicted individuals to be the among the most challenging for therapists. DBT has established itself as one of the most effective treatments for treatment retention of these patients and for reducing parasuicidal and self-injurious behaviors. This study is one of two in a multi-site RCT for the treatment of opiate addiction. DBT has been shown to be efficacious for the treatment of BPD patients and it has been extended in this study to target addictive behaviors in these patients. The study consists of three treatment parts: weekly individual and group therapy and suboxone maintenance medication. Participants are provided therapy on a weekly basis for one year and suboxone for 2 years. Assessments for tracking outcome are conducted every 4 months. It is hypothesized patients in the DBT condition will show a reduction of substance use, parasuicidal and other psychological difficulties and these gains will be maintained through the year of follow-up assessments. In addition, it is predicted that adherence to DBT treatment protocols will be associated with improved outcomes. Finally, it is predicted that treatment "dosage" (average hours of therapy/week) will be positively related to clinical improvement.
NCT00218595 — Dialectical Behavior Therapy
Status: Completed
http://inclinicaltrials.com/dialectical-behavior-therapy/NCT00218595/
Addiction Treatment in Russia: Oral and Depot Naltrexone
Heroin addiction is a growing problem in Russia; individuals who enter heroin addiction treatment often relapse. Therefore, effective heroin addiction treatments are necessary to prevent relapse. The purpose of this study is to compare oral naltrexone with a naltrexone implant that provides opioid blockade for two months in preventing relapse to heroin addiction in St. Petersburg, Russia.
NCT00218426 — Opioid-Related Disorders
Status: Completed
http://inclinicaltrials.com/opioid-related-disorders/NCT00218426/
CBT and Modafinil for Cocaine Addiction
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Modafinil, a medication that enhances mood, increases energy, and improves concentration, may be useful in preventing relapse among individuals with cocaine addiction. This study will evaluate the effectiveness of modafinil, in combination with cognitive behavior therapy (CBT), to prevent drug relapse among cocaine addicts.
NCT00218387 — Cocaine Dependence
Status: Completed
http://inclinicaltrials.com/cocaine-dependence/NCT00218387/
Breastfeeding Among Methadone Maintained Women
Methadone is a drug that offers significant therapeutic benefits to opiate dependent women who are pregnant. Currently, it is the treatment of choice for this group of people. The purpose of this study is to determine the amount of methadone in the breast milk of women who are breastfeeding and taking methadone for opiate addiction. In addition, this study will evaluate the effects of methadone on infant neurobehavior.
NCT00218010 — Opioid-Related Disorders
Status: Completed
http://inclinicaltrials.com/opioid-related-disorders/NCT00218010/