Can Propionibacterium Acnes Load in Primary Shoulder Surgery be Reduced With Preoperative Application of a Benzoylperoxid/Miconazolnitrat crème Additional to Standard Antibiotic Prophylaxis
60 patients undergoing first time open shoulder surgery (Latarjet, prosthesis) will be prospectively included in this study. The investigators will do a randomized controlled trial, choosing with a single-blinded protocol 30 patients for local therapy and other 30 patients as the control group without any treatment preoperative. In the preoperative consultation 30 patients will get Acne Crème Plus (Benzoylperoxid and Miconazolnitrat) to apply until operation (on average 7 days) after receiving written consent. The application should be done daily in the evening on the planned operative side covering the skin from the nipple-areola complex laterally to the medial margin of the scapula and from a horizontal line through the nipple-areola complex cranially over the shoulder and dorsally to the spina scapulae. 30 patients will be included in the control group. Those patients will not get the local therapy in the preoperative consultation but they will need to give written consent for taking swabs for culture samples pre- and intraoperative. In the operation room there will be done from each of the 60 patients a superficial skin swab before doing disinfection, a swab of the subcutaneous layer and a swab of the deep layer (joint capsule). All the three swabs from each of the 60 patients will be sent to Unilabs, Labor für Medizinische Analytik AG, Dübendorf, Switzerland to streak on agar plates to cultivate under anaerobic conditions for 14 days. Propionibacterium acnes will be identified by use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
NCT03949751 — Shoulder Infections
Status: Completed
http://inclinicaltrials.com/shoulder-infections/NCT03949751/
Prevalence of Helicobacter Pylori in Patients With Acne Vulgaris
The objective of the study is to investigate prevalence of H.Pylori infection among acne vulgaris patients.
NCT03411733 — Acne Vulgaris
Status: Completed
http://inclinicaltrials.com/acne-vulgaris/NCT03411733/
A Single-center, Double-blind, Controlled Study to Evaluate the Effect of Next Science™ Acne Cream on Mild to Moderate Facial Acne in Adult Females Over 6 Months.
To assess facial acne vulgaris clinical and psychological outcomes by measuring differences in lesions counts, investigator global assessment, and subjects quality of life scores over 6 months in adult females treated with Next Science™ acne cream 2x or Next Science™ acne cream 1x in a double blind manner.
NCT03106766 — Acne Vulgaris
Status: Terminated
http://inclinicaltrials.com/acne-vulgaris/NCT03106766/
Impact of the M22-IPL Acne Filter on Acne Vulgaris
Up to 20 healthy subjects age 15-45 years old ,Skin Phototype I-V,Study will be conducted in 1 site. Primary objectives is to evaluate the efficacy of IPL acne filter treatment for improvement of acne vulgaris as assessed by lesion count.
NCT02180282 — Acne
Status: Terminated
http://inclinicaltrials.com/acne/NCT02180282/
Evaluation of the Role of Propionibacterium Acnes in the Inflammatory Lesions Associated With Acne Vulgaris
The purpose of this study is to determine the response of acne patients and healthy control patients to the P. acnes bacteria. Half a tube of blood will be drawn from all participants to determine whether or not they have antibodies to the P. acnes bacterium. Anywhere from 1 to 4 skin biopsies of acne pimples or normal control skin will be taken from all subjects for further analysis in the lab to determine whether the inflammation in these pimples can be reduced using anti-P.acnes antibodies.
NCT01929057 — Acne
Status: Completed
http://inclinicaltrials.com/acne/NCT01929057/
Epigallocatechin-3-Gallate Improves Acne in Humans by Modulating Intracellular Molecular Targets and Inhibiting P. Acnes
Epigallocatechin-3-gallate (EGCG) may improve acne vulgaris - major polyphenolic constituent in green tea - known as potent anti-carcinogenic, anti-inflammatory, anti-proliferative, and antimicrobial activities - lipid-lowering and antiandrogenic properties was reported - EGCG can improve acne vulgaris via one of the above mentioned actions.
NCT01687556 — Acne Vulgaris
Status: Completed
http://inclinicaltrials.com/acne-vulgaris/NCT01687556/
Acne Free vs. Proactiv for the Treatment of Moderately Severe Acne Vulgaris
The purpose of this study is to compare the effectiveness of two over the counter acne products in subjects with moderate severity acne vulgaris. The two products being compared in this study are Acne Free "Severe Acne Line" manufactured by University Medical Products, and Proactiv® manufactured by Guthy-Renker.
NCT00913185 — Acne
Status: Completed
http://inclinicaltrials.com/acne/NCT00913185/
Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Moderate to Moderately Severe Facial Acne Vulgaris
The purpose of the study is to determine the development of microbial resistance when using one of two topical acne therapies for the treatment of facial acne vulgaris.
NCT00841776 — Acne
Status: Completed
http://inclinicaltrials.com/acne/NCT00841776/
A Clinical Trial to Evaluate the Effectiveness of an Acne Serum in Improving Facial Acne and Post-Acne Pigmentation
This study will evaluate the efficacy of the Rael Miracle Clear Complete Acne Serum product in improving facial acne and post-acne pigmentation. This study will last for 56 days. The study will be conducted as a single-arm trial where all participants will use the test products. Participants will be required to complete questionnaires at Baseline, Day 1, Day 3, Day 7, Day 14, Day 28, and Day 56. Photos will be taken at Baseline, Day 28, and Day 56. The photos from Baseline and Day 56 will undergo expert skin grading
NCT06120452 — Acne
Status: Recruiting
http://inclinicaltrials.com/acne/NCT06120452/
Sodium Channel Mutations (SCN9A, SCN10A) in the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)
The goal of this observational study is to learn about sodium channel (Nav) mutations in patients with the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES). This study will give more insight into the pathophysiology of ACNES, which is still largely unknown. The primary objective is to determine if there are mutations of Nav1.7 and Nav1.8 in patients with ACNES. Therefore, one blood sample will be drawn, in which the mutations will be analyzed.
NCT05877274 — Chronic Pain Syndrome
Status: Recruiting
http://inclinicaltrials.com/chronic-pain-syndrome/NCT05877274/