Genetic Study of Idiopathic Scoliosis in a Cohort of Families (SCOGEN)

Scoliosis Idiopathic Clinical Trial

— SCOGEN  

Official title:

Genetic Study of Idiopathic Scoliosis in a Cohort of Families

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05116436
• Other study ID #: 2019-A03136-51
• Status: Recruiting
• Start date: June 6, 2020
• Est. completion date: June 6, 2022

Study information

• Verified date: November 2021
• Source: Ramsay Générale de Santé
• Contact: Jean-François Oudet
• Phone: 0683346567
• Email: jf.oudet[@]ecten.eu
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will focus on a large cohort of multiplex families, to precisely identify candidate genes. The fact of have a large database (fifty families, collected by the principal investigator for more than two decades), will contribute to the discovery of genes of interest. It will also allow testing for the presence or absence of mutations found in other cohorts in previous studies. The main objective of this study is to identify genetic abnormalities associated with the presence and severity of idiopathic scoliosis, in families of scoliosis.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 43
• Est. completion date: June 6, 2022
• Est. primary completion date: June 6, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

Inclusion criteria for "sick" patients:

• Presence of idiopathic scoliosis, diagnosed by a clinical examination by an orthopedic doctor and confirmed by the presence of a Cobb angle greater than 10 ° on radiographs of the spine

• Signed informed consent

• Affiliation to a social security scheme or beneficiary of such a scheme

Inclusion criteria for "healthy relatives":

• Be related to the first or second degree with at least 2 individuals suffering from idiopathic scoliosis, and whose family tree over 3 generations finds at least 3 cases of idiopathic scoliosis

• Do not present with scoliosis (clinical examination by an orthopedic doctor and x-rays of the spine).

• Affiliation to a social security scheme or beneficiary of such a scheme

Exclusion Criteria:

Non-inclusion criteria for "sick" patients:

• Be part of one of the following categories of vulnerable people: protected adults, adults unable to express their consent and not subject to a protection measure, pregnant women, parturients and nursing mothers, people deprived of their liberty, people hospitalized without consent, people admitted to a health or social establishment for purposes other than research

• Suspicion of scoliosis secondary to clinical examination

Non-inclusion criteria for "healthy relatives":

• Be part of one of the following categories of vulnerable people: protected adults, adults unable to express their consent and not subject to a protection measure, pregnant women, parturients and nursing mothers, people deprived of their liberty, people hospitalized without consent, people admitted to a health or social establishment for purposes other than research

• Discovery of scoliosis during research (if scoliosis of an idiopathic nature: patient included in the cohort of patients, if secondary scoliosis: exclusion from the family).

All patients :

Pregnancy in progress or desired with discontinuation of contraception (contraindication to the realization of x-rays).

Related Conditions & MeSH terms

• Scoliosis
• Scoliosis Idiopathic

Intervention

Procedure:
• Blood sample
It will test the presence or absence of genetic mutations found in other cohorts in previous studies.
• Spine X-ray
To determine the scoliosis

Locations

Country	Name	City	State
France	Clinique Maussins-Nollet	Paris

Sponsors (2)

Lead Sponsor	Collaborator
Ramsay Générale de Santé	European Clinical Trial Experts Network

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Presence of a mutated allele in scoliosis patients versus their healthy relatives.		12 months