Clinical Trials Logo

Scleroderma, Diffuse clinical trials

View clinical trials related to Scleroderma, Diffuse.

Filter by:

NCT ID: NCT02166229 Withdrawn - Systemic Sclerosis Clinical Trials

Divalproex Sodium in the Treatment of the Cutaneous Manifestations of Scleroderma

Start date: June 2014
Phase: Phase 1/Phase 2
Study type: Interventional

To investigate the ability of divalproex sodium, a histone deacetylase inhibitor, to improve the digital manifestations of scleroderma including digital edema, calcinosis cutis, digital ulcers, and joint contractures.

NCT ID: NCT01639573 Withdrawn - Scleroderma Clinical Trials

Campath-1h Phase I/II Pilot Trial as Immunoablative Therapy for Refractory Systemic Sclerosis

CAMPATH-1H
Start date: April 2011
Phase:
Study type: Observational

This phase I/II pilot trial seeks to demonstrate that prolonged administration of Campath-1H without prior marrow or stem cell harvesting can result in immunoablation similar to that achieved by hematopoietic stem cell transplantation (HSCT) from either bone marrow or peripheral blood stem cell sources in children and adolescents with severe treatment refractory systemic sclerosis (SSc).

NCT ID: NCT01497743 Withdrawn - Scleroderma Clinical Trials

Probiotics in Patients With Moderate-to-severe Distention/ Bloating From Systemic Sclerosis

PRISS
Start date: February 2012
Phase: Phase 4
Study type: Interventional

Organs of the gastrointestinal tract include the mouth, throat, stomach, intestines, and anus. Patients with scleroderma often have GIT disorders. GIT disorders can be severely debilitating and even life-threatening. Some problems associated with GIT disorders may include heartburn, loss of voice or hoarseness, ulcers (open sores), difficulty swallowing, constipation, diarrhea, malabsorption (impaired absorption of nutrients from the GI tract), diminished peristalsis (decreased in the wavelike motion in the muscles of the intestines), and the inability to control your bowel movements. Probiotics are the "good bacteria" normally found in your digestive tract. Our group is looking at whether or not taking daily probiotics (lactobacillus) can help alleviate some of these symptoms in scleroderma patients that have GIT disorders.

NCT ID: NCT01202045 Withdrawn - Clinical trials for Hypertension, Pulmonary

Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients

Start date: September 2010
Phase: N/A
Study type: Observational

The purpose of this study is to assess the value in terms of sensitivity, specificity and likelihood ratio of the stress echocardiography in the screening of pulmonary arterial hypertension in patients with systemic sclerosis and indirect signs of pulmonary arterial hypertension.

NCT ID: NCT01047072 Withdrawn - Clinical trials for Systemic Scleroderma

Low-Dose Conditioning Followed by Donor Stem Cell Transplant in Treating Patients With Severe Systemic Sclerosis

Start date: n/a
Phase: Phase 2
Study type: Interventional

The purpose of the study is to see how well reduced intensity conditioning followed by a stem cell transplant from a donor (allogeneic) works in treating patients with severe systemic sclerosis. In an allogeneic stem cell transplant procedure, stem cells are taken from a healthy donor and transplanted into the patient. Stem cells can be donated by a family member or an unrelated donor who is a complete tissue type match.