Sciatica Clinical Trial
Official title:
Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department: A Randomized, Double-Blind, Controlled Trial.
Currently, Paracetamol and Ibuprofen are widely used by emergency physicians in Turkey for
the pain treatments.
The objective of the study was to assess whether intravenous Paracetamol has superior
Sciatica pain reduction will compare with Ibuprofen in emergency department (ED) adults.
Half of the participants will receive Paracetamol and the other half will receive Ibuprofen.
Paracetamol and Ibuprofen each relieve pain witf different mechanisms.
Paracetamol is termed a simple analgesic and an antipyretic. Despite enduring assertions
that it acts by inhibition of cyclooxygenase (COX)-mediated production of prostaglandins,
unlike non-steroidal anti-inflammatory drugs (NSAIDs).
Ibuprofen is the most commonly used and most frequently prescribed NSAID. It is a
non-selective inhibitor of cyclo-oxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2).4 Although
its anti inflammatory properties may be weaker than those of some other NSAIDs, it has a
prominent analgesic and antipyretic role.
In our trial; The investigators aimed to compare intravenous Paracetamol and Ibuprofen in
patient with Sciatica
- All patients eligible for the study(Approximately 200 patient with sciatica) were
randomized to one of two groups:
- First Group: 1000 mg Paracetamol in 150 ml normal saline given as a slow intravenous
infusion over 5 minutes.
- 100 ml of saline is removed before the addition of the 100 ml paracetamol to be the
same volume.
- Second Group: 400 mg Ibuprofen in 150 ml normal saline given as a slow intravenous
infusion over 5 minutes.
- Drug packs were prepared according to the computer-generated random number sequence to
assign treatment allocations
- The allocation list was kept by the emergency nurse. Patients received the paracetamol
or Ibuprofen medication schemes according to their random allocations.
- After enrollment and recording of baseline information, the next numbered study drug
pack was obtained, and administered as a infusion over 5 minutes.
- Randomization was achieved by using computer software to generate random numbers.
- One researcher blinded to patient allocation observed the whole procedure and recorded
the Sciatica pain scores.
- Patients in both groups received two types of medication in a similar manner (for
example, 150 ml normal saline given as a slow intravenous infusion over 5 minutes),
thus ensuring double blinding.
- Sciatica pain scores were recorded at 0, 15, and 30 min on a VAS of 1 to 10
- Rescue medication is given patients If the clinician think it's necessary within 30
minutes after study drug administration.
- All other medications required during the study also were recorded.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02384928 -
Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation
|
N/A | |
Completed |
NCT05626140 -
COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
|
Phase 3 | |
Withdrawn |
NCT02313350 -
Intradiscal Discogel® in Resistant Sciatica
|
N/A | |
Unknown status |
NCT02512081 -
"The Lived Experience of Investigations for Sciatica"
|
N/A | |
Recruiting |
NCT06179901 -
The Effect of Early MSAT Treatment on Sciatica Caused by Traffic Accidents
|
N/A | |
Terminated |
NCT02951377 -
Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy
|
Phase 1 | |
Completed |
NCT03347929 -
NSAIDs in Sciatica NSAIDS IN SCIATICA
|
Phase 4 | |
Completed |
NCT04145310 -
BOL-DP-o-04 in Patients With Low Back Pain and Sciatica
|
Phase 1/Phase 2 | |
Enrolling by invitation |
NCT04660656 -
Predictive Value of the Five-repetition Sit-to-stand Test After Lumbar Spine surgerySTS-3 Study.
|
||
Completed |
NCT02644421 -
Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica)
|
Phase 1 | |
Completed |
NCT00991172 -
A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain
|
Phase 2 | |
Completed |
NCT00668434 -
Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica
|
Phase 2 | |
Completed |
NCT00749996 -
Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease
|
Phase 4 | |
Completed |
NCT00246948 -
The Efficacy of Active Conservative Treatment for Patients With Severe Sciatica. A Randomized Clinical Controlled Trial
|
N/A | |
Completed |
NCT04155450 -
Effects of Extension Biased External Limb Loading in Addition to McKenzie Extension Protocol in Lumbar Derangement Syndrome
|
N/A | |
Completed |
NCT02284542 -
NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators
|
||
Recruiting |
NCT02770963 -
Efficacy of Acupuncture for Discogenic Sciatica
|
N/A | |
Completed |
NCT00364572 -
Efficacy of Epidural Etanercept in the Treatment of Sciatica
|
Phase 1/Phase 2 | |
Completed |
NCT00470509 -
Adalimumab in Severe and Acute Sciatica
|
Phase 2 | |
Active, not recruiting |
NCT03887962 -
Virtual Environment Rehabilitation for Patients With Motor Neglect Trial
|
N/A |