Upside Down, Give me the Handle

Schizophrenic Disorders Clinical Trial

Official title:

Study on the Links Between Perception and Action in Schizophrenia, "Upside Down, Give me the Handle"

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02544516
• Other study ID #: 1308139
• Secondary ID: 2013-A01294-41
• Status: Completed
• Phase: N/A
• First received: September 7, 2015
• Last updated: November 21, 2016
• Start date: April 2014
• Est. completion date: October 2016

Study information

• Verified date: November 2016
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Agence Nationale de Sécurité du Médicament et des produits de santé
• Study type: Interventional

Clinical Trial Summary

In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible (Fuchs, 2005). However, automatic integration between perception and action is the necessary condition to be in "relationship with the world." Affordance is the experimental link between object perception and actions potentially associated (Gibson (1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. The existence of visual motor neurons leads us to postulate that the affordance effect can be assisted by a visuomotor priming of a hand in a position to grasp. With Tucker & Ellis sensory motor compatibility task, we study the capacity of affordance in schizophrenia, as well as the impact of perceptual motor priming on these affordance effects.

Description:

All participants will perform cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987). Controls will only have the first three tasks (cognitive spots Alert and laterality). Then all will perform all tasks in successive order (task 1 and task 2). For both tasks, photographs of 20 objects of everyday life typical grip with one hand are presented in 4 orientations. The instruction is to say if the object is presented upright or inverted; The second task differs from the first only by the introduction of a prime: presenting a hand in position "catching" before the picture of an object

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: October 2016
• Est. primary completion date: October 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

For patients:

• a DSM-IV diagnosis of schizophrenia (men or women),

• no change in antipsychotic medication and clinical status within four weeks prior to the study

Exclusion Criteria:

• IQ < 70

For patients and control group Inclusion criteria

• Age = 18 years et = 50 years

Exclusion Criteria:

• History of head trauma,

• neurological disease with cerebral repercussion or not stabilized serious physical illness;

• psychotropic medication,

• disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Schizophrenia
• Schizophrenic Disorders

Intervention

Other:
• cognitive tasks + PANSS+ IQ
Patients will have cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987
• cognitive tasks
Patients will have cognitive tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971),

Locations

Country	Name	City	State
France	CHU de SAINT-ETIENNE	Saint-etienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	response time	The gain provided by the compatible vs incompatible conditions (ms response time)	day 1	No