Personalised Cognitive Remediation Therapy (pCRT) — pCRT  

Schizophrenia Schizoaffective Clinical Trial

Official title: Testing the Feasibility and Acceptability of a New Personalised Form of Cognitive Remediation Therapy (pCRT) for People With Psychosis.

Status Not yet recruiting

Clinical Trial Summary

Cognitive deficits have been shown to have negative impact on social functioning and functional goals such as ability to work and perform daily tasks in people with schizophrenia. There is evidence that Cognitive Remediation Therapy, a form of psychological therapy, is effective in improving cognition and functioning but there is still a limited understanding of what influence people's different response to this therapy. A tailored treatment is likely to be more effective because it will adapt to service users' unique characteristics.

The investigators are planning a study exploring at the feasibility and acceptability of novel form of Cognitive Remediation Therapy which is personalised (pCRT) to the person individual characteristics. The personalised therapy will consist of task practice using computerized Cognitive Remediation software (i.e. called CIRCuiTS). The knowledge gathered in this work will contribute to develop the next generation of personalised treatment approaches for people with schizophrenia.

Clinical Trial Description

Cognitive deficits in people with psychosis have been shown to have negative impact on functional goals including the ability to work and perform daily tasks. Cognitive Remediation Therapy (CRT) is a psychological therapy developed to improve cognitive functions in people with schizophrenia but ultimately with a focus on improving social and functional outcomes. There is evidence that CRT is effective in improving cognition and functioning but there is still a limited understanding of the mechanisms responsible for different treatment responses. This study attempts to fill this gap by developing and testing a new form of CRT, which will personalise therapy elements according to participants' characteristics. The therapy will consist of task practice using a computerised Cognitive Remediation software and supervised activities supported by a therapist to boost functioning. The knowledge gathered in this work will contribute to develop the next generation of personalised treatment approaches for people with schizophrenia. ;

Related Conditions & MeSH terms

• Psychotic Disorders
• Schizophrenia
• Schizophrenia Schizoaffective

• NCT number: NCT03461432
• Study type: Interventional
• Source: King's College London
• Contact: Benedetta Seccomandi, PhD student
• Phone: 02078485728
• Email: benedetta.seccomandi@kcl.ac.uk
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 31, 2018
• Completion date: December 31, 2019