The Efficacy of Neural Stimulation in Individuals With Schizophrenia

Status Active, not recruiting

Clinical Trial Summary

The purpose of this study is to understand the relationship between psychotic symptoms and social functioning in individuals with schizophrenia spectrum disorders. Our goal is to determine whether stimulating the brain using transcranial Direct Current Stimulation (tDCS) can improve symptoms and daily functioning.

Clinical Trial Description

Paranoid ideation is a common delusion experienced by individuals with schizophrenia spectrum disorders (SSD) that negatively impacts social interactions and quality of life. Therefore, efforts to reduce paranoid thinking via neuromodulation techniques [e.g., transcranial direct current stimulation (tDCS)] are in development, with amygdala-prefrontal cortex (PFC) circuits targeted as critical components of the neural mechanisms underlying paranoia. This project aims to alleviate paranoia and improve social functioning in individuals with SSD by implementing tDCS to ventrolateral PFC. A double-blind, within-subjects, crossover design will be used to compare the effects of active vs. sham tDCS. Ecological Momentary Assessments (EMA) will also be utilized to quantify any delayed stimulation effects in daily social interactions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05746494
Study type	Interventional
Source	The University of Texas at Dallas
Contact
Status	Active, not recruiting
Phase	N/A
Start date	November 21, 2022
Completion date	May 2025

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