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NCT03187366 Clinical Trial

Schistosomiasis in Senegal

Schistosomiasis Clinical Trial

Official title:
EID: Using Community Ecology Theory to Predict the Effects of Agricultural Expansion and Intensification on Infections of Humans: Implications for Sustainable Agriculture

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT03187366
Other study ID # R01TW010286
Secondary ID
Status Active, not recruiting
Phase N/A
First received
Last updated
Start date January 2, 2017
Est. completion date September 2025

Study information
Verified date March 2023
Source University of Notre Dame
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Schistosomiasis is a flatworm transmitted from freshwater snails to humans in the tropics. In addition to this infectious disease, tropical developing countries are faced with malnutrition. We propose to alter pesticide and compost use to reduce schistosomiasis and maintain or even improve crop production.

Description:

We propose two types of manipulations. Bottom-up manipulations will affect snail resources, whereas top-down manipulations will affect snail predators. For the bottom-up manipulations, we will clear schistosoma infections in school children, then remove the primary habitat for snails, the submerged macrophyte Ceratophyllum demersum (with proper unmanipulated controls), compost it, apply it to crops, and then quantify reinfection rates and crop yields. The second bottom-up manipulation will be to clear schistosoma infections in school children, apply three agrochemical treatments (status quo control, shift to lower risk herbicides, or eliminate herbicides and fertilizers), and then quantify reinfection rates and crop yields. Farmers will be compensated for any loss in yields. For the top-down manipulations, every village will receive prawns that depredate snails. We will clear schistosoma infections in school children, apply three agrochemical treatments (status quo control, shift to lower risk insecticides that don't kill prawns, or eliminate insecticides), and then quantify reinfection rates and crop yields. Farmers will be compensated for any loss in yields.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 1477
Est. completion date September 2025
Est. primary completion date September 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 5 Years to 17 Years
Eligibility Inclusion Criteria: - School age children Exclusion Criteria: - Non-school age children

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Bottom-up intervention
Some interventions are bottom-up, where we manipulate the resources of snails and some are top-down, where we manipulate the predators of snails.

Locations
Country Name City State
Senegal Espoir Pour La Santé (EPLS) Saint-Louis

Sponsors (2)
Lead Sponsor Collaborator
University of Notre Dame Biomedical Research Center EPLS

Country where clinical trial is conducted

Senegal, 

Outcome
Type Measure Description Time frame Safety issue
Primary Schistosomiasis reinfection rate Schistosomiasis reinfection rate One year
Secondary Crop yields Crop yields One year
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