Sm-p80 Schistosomiasis Challenge Study

Status Not yet recruiting

Clinical Trial Summary

The goal of this clinical trial is to learn about the Sm-p80 + GLA-SE (Schistoshield®) vaccine in healthy participants who have not had schistosomiasis before. The main questions it aims to answer are: - if the vaccine is safe - if after vaccinated people start producing antibodies - if the vaccine works against schistosomiasis. Participants will receive three vaccines (or placebo) and are then exposed to 20 male Schistosoma cercariae. Afterwards they are treated with praziquantel to cure the infection. Researchers will compare the group vaccinated with Schistoshield® and placebo (fake vaccination) to see if the vaccine has worked.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05999825
Study type	Interventional
Source	Leiden University Medical Center
Contact	Meta Roestenberg, Prof
Phone	+31715269111
Email	M.Roestenberg@lumc.nl
Status	Not yet recruiting
Phase	Phase 2
Start date	September 2024
Completion date	September 2025

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See also
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