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Clinical Trial Summary

The goal of this clinical trial is to learn about the Sm-p80 + GLA-SE (Schistoshield®) vaccine in healthy participants who have not had schistosomiasis before. The main questions it aims to answer are: - if the vaccine is safe - if after vaccinated people start producing antibodies - if the vaccine works against schistosomiasis. Participants will receive three vaccines (or placebo) and are then exposed to 20 male Schistosoma cercariae. Afterwards they are treated with praziquantel to cure the infection. Researchers will compare the group vaccinated with Schistoshield® and placebo (fake vaccination) to see if the vaccine has worked.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05999825
Study type Interventional
Source Leiden University Medical Center
Contact Meta Roestenberg, Prof
Phone +31715269111
Email M.Roestenberg@lumc.nl
Status Not yet recruiting
Phase Phase 2
Start date September 2024
Completion date September 2025

See also
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