Scar Clinical Trial - Effectiveness of Botulinum Toxin A in Preventing

Status Completed

Clinical Trial Summary

Each year, millions of burn, trauma, or surgical patients worldwide suffer from scarring that severely affects their quality of life and social functioning. In order to prevent and treat diseases related to abnormal scar hyperplasia, clinicians and researchers have adopted various methods, such as scar grinding, surgical resection, drug injection in scar tissue, cryotherapy, laser and so on. However, these methods can not effectively inhibit the abnormal proliferation of scars and improve the adverse effects of existing scars on patients. To date, there is no accepted gold standard for the effective treatment and improvement of abnormal scar tissue.

Clinical Trial Description

Through a large number of literature review and preliminary experiments, we summarized and found the following problems: a. The latest research on prevention of scar formation by botulinum toxin type A is only aimed at surgical wounds from the wound type, and there is no research on the scar prevention effect of trauma wounds. b. From the point of view of the study site, there is no study on the effect of scar prevention only on the head, neck, chest and other parts of the body. c. For the research results of botulinum toxin type A in the prevention of scarring, the current research focuses on the effectiveness of botulinum toxin type A at a certain concentration, and does not compare the effects of botulinum toxin type A at various concentrations.Therefore, in order to explore the "optimal concentration" of botulinum toxin type A to prevent scar formation; To explore the effect of botulinum toxin A on scar prevention of traumatic wounds and surgical incisions. To explore the effect of botulinum toxin A on scar prevention in other parts of the body in addition to effective prevention of head, neck and chest scar, We intend to focus on the effectiveness and "optimal concentration" of botulinum toxin type A to prevent scarring, to determine the effect of this means on scar prevention, to provide new ideas for botul ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06437912
Study type	Interventional
Source	Dezhou Hospital Qilu Hospital of Shandong University
Contact
Status	Completed
Phase	Early Phase 1
Start date	March 23, 2023
Completion date	March 31, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03646955` - Partial Breast Versus no Irradiation for Women With Early Breast Cancer	N/A
Completed	`NCT01706848` - Celotres for Improvement in Wound Healing and Resulting Scar Consequences Following Suturing of a Wound	N/A
Recruiting	`NCT01177358` - Botox in the Healing of Surgical Wounds of the Neck	Phase 2
Terminated	`NCT01459666` - Forehead Scars Following Mohs Micrographic Surgery and Reconstruction for Skin Cancer	Phase 4
Completed	`NCT00970671` - Treatment of Surgical Scars Using the Pulsed Dye Laser	N/A
Recruiting	`NCT03561376` - Zinc Oxide Versus Petrolatum Following Skin Surgery	Early Phase 1
Completed	`NCT05293652` - Effect of Hydrocortisone Iontophoresis Versus Hydrocortisone Phonophoresis On Post Surgical Scar	N/A
Recruiting	`NCT03406143` - Evaluation of the Effect of CGF in Promoting Mechanical-stretch Induced in Vivo Skin Regeneration	N/A
Completed	`NCT05527756` - Evaluation of the Cosmetic Outcomes of Totally Endoscopic Cardiac Surgery
Completed	`NCT02886988` - Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection	Phase 2/Phase 3
Completed	`NCT05618912` - Scar Appearance After Postoperative Hydrocolloid Dressing Versus Standard Petrolatum Ointment	N/A
Recruiting	`NCT05408117` - Impact of Suture Type on Pigment Disturbances in Patients of Skin of Color	N/A
Completed	`NCT04169438` - Pilot Study Investigating a Restorative Wound Care Cream Together With Petrolatum on Surgical Excisions	N/A
Terminated	`NCT02520557` - An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate
Not yet recruiting	`NCT04621994` - Cesarean Wound Closure: Dermabond Versus Steri Strips	N/A
Withdrawn	`NCT03395678` - Acne Scarring in Skin of Color: Laser vs Microneedling	N/A
Completed	`NCT02744950` - Comparison of Scar Results and Time for Closures of Scalp Defects Via Pulley Sutures or Layered Repairs	N/A
Not yet recruiting	`NCT01005992` - Fractional Photothermolysis for the Treatment of Burn Scars	Phase 1
Completed	`NCT04870008` - Aesthetic Outcome of Running Cuticular Suture Distance (2mm vs 5mm)	N/A
Recruiting	`NCT04506255` - Silicone Taping for the Improvement of Abdominal Donor Site Scars	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effectiveness of Botulinum Toxin A in Preventing Scar Formation and Initial Exploration of "Optimal Concentration"

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms