Botulinum Toxins Intralesional Injection for Scar Pain

Status Recruiting

Clinical Trial Summary

Botulinum toxins has been approved by the FDA to treat chronic migraine. Botox had been shown to inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerve to treat neuropathic pain. In the clinical practice, botox indeed effect in scar pain. However, investigators need well controlled study to prove this finding and assess the improvement of scar appearance.

Clinical Trial Description

After surgery or trauma, scar tissues would form during the healing process. However, hypertrophic scars and keloids might happen to some patients, both of which are often pruritic and erythematous. Besides, the markedly elevated tumor-like appearance usually brings much concern to patients. Moreover, significant pain or discomfort could happen to keloids. Various treatment strategies were mentioned but without a solid solution to all of the scars. Investigators hope to evaluate the differences of scar volume, appearance and symptoms (itching and pain) in participants receiving simultaneous intralesional injection of Botulinum toxin type A and/or steroids. Besides, side effects would also be recorded. Investigators hope to establish a more effective intralesional injection therapy for participatns suffering from hypertrophic scars and keloids. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03982862
Study type	Interventional
Source	Kaohsiung Medical University
Contact	Shu hung Huang, MD, PHD
Phone	886-3121101
Email	huangsh63@gmail.com
Status	Recruiting
Phase	Phase 4
Start date	July 30, 2018
Completion date	June 30, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03376620` - Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients	Phase 3
Terminated	`NCT03935594` - Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars	Phase 2
Recruiting	`NCT03561376` - Zinc Oxide Versus Petrolatum Following Skin Surgery	Early Phase 1
Recruiting	`NCT06033430` - Effectiveness of Dry Needling in Linear Scar Tissue	N/A
Recruiting	`NCT03631368` - Treatment of Hypertrophic Scars With Intradermal Botox	Phase 2
Completed	`NCT03630198` - Pain Outcomes Following Intralesional Corticosteroid Injections	Phase 4
Recruiting	`NCT02168634` - The Use of Botulinum Toxin in the Treatment of Itching From Hypertrophic Scar -- A Randomised Controlled Trial	N/A
Completed	`NCT02030275` - A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults	Phase 2
Recruiting	`NCT04506255` - Silicone Taping for the Improvement of Abdominal Donor Site Scars	N/A
Not yet recruiting	`NCT04593706` - Comparison of the Efficacy of Different Steroids in the Treatment of Abnormal Scars (Keloids, Hypertrophic Scars)	N/A
Completed	`NCT04643223` - Effect of Elastic Bandage With Tension on the Inflammatory Response of Hypertrophic Scars	N/A
Completed	`NCT03986346` - The Vascularity Changes of Scars With Laser Therapy	N/A
Completed	`NCT04619589` - Characterization of Dyschromic Hypertrophic Scar
Completed	`NCT05412745` - Class I Medical Device on Post-surgical Scars	N/A
Completed	`NCT06347081` - Effect of Nd-YAG Laser on Hypertrophic Scar	N/A
Terminated	`NCT03403621` - Hypertrophic Scar Prevention by Novel Topical Gel Application	Phase 1/Phase 2
Completed	`NCT00754247` - A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars	Phase 4
Recruiting	`NCT03692273` - Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar	N/A
Completed	`NCT03795116` - Light Emitting Diode-Red Light (LED-RL) Phototherapy for Skin Scarring Prevention	Phase 2
Not yet recruiting	`NCT03850119` - Nanofat on Wound Healing and Scar Formation	N/A