SARS-CoV-2 Clinical Trial
Official title:
Study of Clinical, Biological and Genetic Prognostic Factors of SARS-CoV-2 Infection in Patients Admitted in the Strasbourg University Hospitals
COVID-19 is an emerging disease, for which no specific treatment options are currently
available. Since the end of February 2020, and due to a SARS-CoV-2 superspreading event
(religious meeting), the Strasbourg University Hospital (HUS) had faced a sudden increase of
the number of COVID-19-positive patients in serious condition requiring hospitalization. At
the same time, many people develop only mild or moderate symptoms. To date, the prognostic
factors for the course of SARS-CoV-2 infection are unknown. The primary purpose of the
"COVID-HUS" protocol is to investigate viral and host-related factors to understand the
pathophysiology of COVID infection and to open the way for new diagnostic, prognostic and
therapeutic strategies against SARS CoV-2 .
The secondary objectives are
- Monitoring of viral replication of SARS-CoV-2 in the blood and respiratory tract in
infected patients
- Monitoring of the humoral and cellular response directed against SARS-CoV-2
- Identification of factors leading to significant and / or prolonged viral replication of
SARS-CoV-2 in the blood or respiratory samples
- Evaluation of the benefit of possible treatments implemented following the diagnosis of
SARS-CoV-2 infection
- Exploration of the B and T immune repertoire sequences targeting SARS-CoV-2 in infected
patients
- Typing of the HLA system in infected patients
n/a
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