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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05833321
Other study ID # CHMS22005
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date November 20, 2022
Est. completion date October 2026

Study information

Verified date June 2023
Source Centre Hospitalier Metropole Savoie
Contact jego florence
Phone 0479965813
Email florence.jego@ch-metropole-savoie.fr
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Prospective monocentric study, non-randomized of the detection of sarcopenia in clinical practice in patients with ovarian or endometrial cancer requiring systemic oncological treatment. main question : Identify the criteria correlated with the presence of sarcopenia (defined by the measurement of the IMS by the CT-X method in L3) among the impedancemetry and the HAS malnutrition criteria. Data collection will be done at 6 months, 12 months after the date of inclusion.


Description:

Primary objective:Identify the criteria correlated to the presence of sarcopenia (defined by the measurement of the IMS by the CT-X method in L3) among the impedancemetry and the HAS malnutrition criteria Main judgment criteria : Comparison between the groups of patients with sarcopenia (Morphometric measurement of the musculoskeletal surface index <39cm²/m² in L3 cross section) and without sarcopenia of the different evaluation criteria: - Impedancemetry values:: muscle mass index in kg/m2 (IMS), fat-free mass in kg/m2 and metabolic activity index (phase angle) - Percentage of weight loss - BMI < 18.5 kg/m2 - Quantified reduction in muscle mass and/or function for patients < 70 years old - Quantified reduction in muscle mass and function for patients > 70 years old - Physical tests: walking speed and "hand grip" dynamometer secondary objectives:- Proposal of a composite score for the detection of sarcopenia usable in clinical routine - Evaluation of nutritional intake - Evaluation of the severity of undernutrition - Verification of a correlation between the sarcopenia indices of ovarian and endometrial cancer - Evaluate tolerance profiles to systemic treatments with regard to sarcopenia figures - Assess the relationship between PFS, OS and sarcopenia index in cancer diagnosis secondary judgment criteria : - Statistical analysis of sarcopenia and undernutrition data - Quantification of ingestates (SEFI scale) +/- intake of oral nutritional supplement - Serological tests: NFS, CRP and Albuminemia - Comparison of sarcopenia index figures between ovarian and endometrial cancer - Collection of the grades of toxicities and adverse events to systemic treatments in parallel with the measurement of sarcopenia. - Correlation between progression-free survival, death and sarcopenia index at cancer diagnosis


Recruitment information / eligibility

Status Recruiting
Enrollment 75
Est. completion date October 2026
Est. primary completion date October 2025
Accepts healthy volunteers No
Gender Female
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patients at least 18 years old - Patient presenting with a diagnosis of cancer of ovarian origin with an indication for chemotherapy - Patient with a diagnosis of endometrial cancer with an indication for chemotherapy - Patient with no diagnosis of other types of cancer in the previous five years - Collection of consent - Patient affiliated to a Social Security scheme Exclusion Criteria: - Patient with cancer of ovarian origin not requiring chemotherapy treatment - Patient with endometrial cancer not requiring chemotherapy treatment - Discovery of an intercurrent cancer other than skin or cervix cancers. - Patient wearing a Pace maker

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
Sarcopenia diagnostic test
measurement of impedance and physical tests ("hand grip" dynamometer, walking test), SEFI nutritional intake questionnaire

Locations

Country Name City State
France Centre Hospitalier Metropole Savoie Chambéry Savoie

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Metropole Savoie

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary clinical screening for sarcopenia Identify the criteria correlated with the presence of sarcopenia (defined by the measurement of the IMS by the CT-X method in L3) among the impedancemetry and the HAS malnutrition criteria. 36 month
Primary Proposal of a composite score for the detection of sarcopenia usable in clinical routine Statistical analysis of sarcopenia and undernutrition data 36 month
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