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Clinical Trial Summary

Prospective monocentric study, non-randomized of the detection of sarcopenia in clinical practice in patients with ovarian or endometrial cancer requiring systemic oncological treatment. main question : Identify the criteria correlated with the presence of sarcopenia (defined by the measurement of the IMS by the CT-X method in L3) among the impedancemetry and the HAS malnutrition criteria. Data collection will be done at 6 months, 12 months after the date of inclusion.


Clinical Trial Description

Primary objective:Identify the criteria correlated to the presence of sarcopenia (defined by the measurement of the IMS by the CT-X method in L3) among the impedancemetry and the HAS malnutrition criteria Main judgment criteria : Comparison between the groups of patients with sarcopenia (Morphometric measurement of the musculoskeletal surface index <39cm²/m² in L3 cross section) and without sarcopenia of the different evaluation criteria: - Impedancemetry values:: muscle mass index in kg/m2 (IMS), fat-free mass in kg/m2 and metabolic activity index (phase angle) - Percentage of weight loss - BMI < 18.5 kg/m2 - Quantified reduction in muscle mass and/or function for patients < 70 years old - Quantified reduction in muscle mass and function for patients > 70 years old - Physical tests: walking speed and "hand grip" dynamometer secondary objectives:- Proposal of a composite score for the detection of sarcopenia usable in clinical routine - Evaluation of nutritional intake - Evaluation of the severity of undernutrition - Verification of a correlation between the sarcopenia indices of ovarian and endometrial cancer - Evaluate tolerance profiles to systemic treatments with regard to sarcopenia figures - Assess the relationship between PFS, OS and sarcopenia index in cancer diagnosis secondary judgment criteria : - Statistical analysis of sarcopenia and undernutrition data - Quantification of ingestates (SEFI scale) +/- intake of oral nutritional supplement - Serological tests: NFS, CRP and Albuminemia - Comparison of sarcopenia index figures between ovarian and endometrial cancer - Collection of the grades of toxicities and adverse events to systemic treatments in parallel with the measurement of sarcopenia. - Correlation between progression-free survival, death and sarcopenia index at cancer diagnosis ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05833321
Study type Interventional
Source Centre Hospitalier Metropole Savoie
Contact jego florence
Phone 0479965813
Email florence.jego@ch-metropole-savoie.fr
Status Recruiting
Phase N/A
Start date November 20, 2022
Completion date October 2026

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