Beetroot Juice Resistance Training Older Adults

Sarcopenia Clinical Trial

Official title:

Effect of Beetroot Juice on Body Composition, Physical Function, Muscle Strength, and Peak Oxygen Consumption in Resistance Trained Older Adults Consuming a Protein Supplement

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05460351
• Other study ID #: IRB00025941
• Status: Completed
• Phase: N/A
• Start date: February 2014
• Est. completion date: May 2015

Study information

• Verified date: July 2022
• Source: Wake Forest University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study compared the effects of a nitrate containing beetroot juice supplement (BRJ+Nitrate) vs. a placebo (Control) on total and regional fat free mass, quadriceps muscle strength, lower body mobility, and VO2peak in healthy, older adults undergoing a 10-week long progressive resistance training program with protein supplementation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: May 2015
• Est. primary completion date: December 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Able to provide own transportation to study testing visits and intervention
• Able to read and write in English
• Nondiabetic, i.e. fasting glucose < 126 mg/dl
• Sedentary (less than 60 minutes of moderate intensity structured physical activity each week and occurs in no more than 10 minute blocks and not participating in a resistance exercise training program)
• Willingness to provide informed consent and participate in intervention. Participants with diagnosed depression were permitted to participate provided that they have been medically stable without medication change for at least 3 months.

Exclusion Criteria:

• Smoking or use of chewing tobacco
• Involved in another intervention research study
• Diabetic (type 1 or 2)
• Atrophic gastritis
• Hypo- or hyperthyroidism
• Gout or history of kidney stones
• History of hypotension
• Premenopausal (women)
• Aversion to study-related testing procedures
• Allergy/sensitivity/aversion to beetroot beverages or protein supplement
• Medical conditions with contraindications for engaging in resistance training program or taking the protein supplement
• Systemic, uncontrolled diseases (diabetes, recent (last 6 months) or current treatment of cancer, thyroid disorders, cardiovascular disease, COPD, or inflammatory bowel diseases)
• Use of any of the following medications: phosphodiesterase type 5 inhibitors, nitroglycerin or nitrate preparations, proton pump inhibitors, or medications for hypothyroidism
• Potential inability to complete the tasks required for the protocol as well as conditions that may interfere with interpretation of results including: inability to ambulate, severe congestive heart failure or severe cardiovascular disease, neoplasm for practical and neurophysiologic reasons
• Individuals with contraindications for performing a graded exercise test or have medical contraindications for participating in a scheduled exercise training program
• Individuals more than 300 pounds or less than 125 pounds due to DEXA weight limits and possibility of exceeding recommended daily nitrate dose of 7 mg/kg body weight, respectively.

Related Conditions & MeSH terms

• Old Age; Atrophy
• Sarcopenia

Intervention

Dietary Supplement:
• BRJ+Nitrate
Participants in this group drank a 70 mL bottle of Beet It Sport drink with nitrate plus 15 grams of whey protein 3 days a week following a resistance exercise training program
• Control
Participants in this group drank a 70 mL bottle of Beet It Sport drink without nitrate plus 15 grams of whey protein 3 days a week following a resistance exercise training program

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Wake Forest University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Whole body fat free mass	Mass of fat free tissue	Collected at baseline
Primary	Whole body fat mass	Mass of fat tissue	Collected at baseline
Primary	Thigh muscle	Volume of thigh muscle	Collected at baseline
Primary	Thigh intermuscular fat	Volume of fat in the thigh muscle	Collected at baseline
Primary	Thigh subcutaneous fat	Volume of subcutaneous fat in the thigh	Collected at baseline
Primary	Visceral fat	Volume of visceral fat	Collected at baseline
Primary	Muscle strength	Strength of quadriceps muscle at a speed of 60 degrees per second	Collected at baseline
Primary	400 meter walk	Time to walk 400 meters	Collected at baseline
Primary	Stair climb time	Time to ascend and descend 12 stairs	Collected at baseline
Primary	Peak oxygen consumption	Peak oxygen consumed at maximal exercise during graded exercise testing	Collected at baseline
Primary	Whole body fat free mass	mass of fat free tissue	Collected at 10-weeks
Primary	Whole body fat mass	Mass of fat tissue	Collected at 10-weeks
Primary	Thigh muscle	Volume of thigh muscle	Collected at 10-weeks
Primary	Thigh intermuscular fat	Volume of fat in the thigh muscle	Collected at 10-weeks
Primary	Thigh subcutaneous fat	Volume of subcutaneous fat in the thigh	Collected at 10-weeks
Primary	Visceral fat	Volume of visceral fat	Collected at 10-weeks
Primary	Muscle strength	Strength of quadriceps muscle at a speed of 60 degrees per second	Collected at 10-weeks
Primary	400 meter walk	Time to walk 400 meters	Collected at 10-weeks
Primary	Stair climb time	Time to ascend and descend 12 stairs	Collected at 10-weeks