| Eligibility |
Inclusion Criteria:
1. Participant must be male or female, ages 65 through 90 years of age.
2. Participant must be sedentary, defined as = 1 structured intentional continuous
exercise session (approximately 30 mins) per week.
3. Participant must be sarcopenic, defined as having a skeletal muscle mass index (SMI)
of <7.25 kg/m2 for males or <5.67 kg/m2 for females via DEXA scan.
4. Participant states willingness to follow the protocol as described and will complete
any forms needed throughout the study.
5. Participant has voluntarily signed and dated an informed consent form, approved by an
Institutional Review Board/Independent Ethics Committee, and provided Health Insurance
Portability and Accountability Act authorization (HIPAA) or other privacy
authorization prior to any participation in study.
Exclusion Criteria:
1. Inability and/or unwillingness to comply with the protocol as written
2. Participant has had a significant cardiovascular event (e.g., myocardial infarction,
stroke) = 6 months prior to screening visit; or stated history of congestive heart
failure; or participant has evidence of cardiovascular disease assessed during the ECG
at screening. In the event of a positive stress test, participants are referred to
their primary care physician. If the electrocardiogram (ECG) is determined to be a
false positive, participant may be allowed to participate in study after confirmatory
records obtained.
3. The presence of any condition which contraindicate moderate exercise and would result
in the inability to comply with the protocol as written or would compromise
participant safety or data integrity, will be considered on a case-by-case basis by
the Principal investigator and the study physician.
4. Participant is actively pursuing weight loss and/or lifestyle changes.
5. History of gastrointestinal or intracranial hemorrhage.
6. History of stroke or cerebrovascular accident.
7. Participant has diabetes.
8. Weight stable -no gain/loss by self-report of = 10 lbs in 6 months prior to screening
9. BMI 40.0 kg/m2
10. Untreated or poorly controlled hypertension (SBP 150, DBP 95), or hypotension (SBP 100
DBP 60)
11. Participant has untreated hyperthyroidism (TSH (0.5mIU/L) or untreated hypothyroidism
(TSH 10mIU/L).
12. Participant has current infection (requiring prescription antimicrobial or antiviral
medication, or hospitalization), or corticosteroid treatment (with the exception of
inhaled or topical steroids) in the last 3 months prior to screening visit.
13. Participant is currently taking anti-inflammatory medication or has had
anti-inflammatory medication within 1 week prior to screening (including over the
counter formulations, e.g., Aleve, Motrin, ibuprofen, naproxen, low dose aspirin).
14. Participant has had surgery requiring > 2 days of hospitalization in the last 1 month
prior to screening visit.
15. Participant has an active malignancy or autoimmune disease.
16. Participant has current significantly impaired liver function in the opinion of the
study Medical Investigator (mild asymptomatic fatty liver is acceptable), or hepatic
enzyme tests are = 2.5 times normal limit.
17. Participant has a chronic, contagious, or infectious diseases, such as active
tuberculosis, Hepatitis B or C, or HIV, per self-report.
18. Participant currently has uncontrolled severe diarrhea, nausea or vomiting.
19. Participant has an obstruction of the gastrointestinal tract, inflammatory bowel
disease, short bowel syndrome or other forms of gastrointestinal disease such as stage
III or above gastroesophageal reflux disease, gastroparesis, peptic ulcer disease,
celiac disease, intestinal dysmotility, diverticulitis, ischemic colitis and bariatric
surgery.
20. Participant has a mini-Mental State Examination score < 21.
21. Unable to participate in DXA assessments due to physical limitations of equipment
tolerances (e.g., DXA 450-pound weight limit), claustrophobia, or based on
Investigator's judgment at screening.
22. Participant has a sensitivity or allergy to lidocaine.
23. Presence of any condition that, in the opinion of the Investigator, compromises
participant safety or data integrity or the participant's ability to complete the
study.
24. Participant has peripheral vascular disease.
25. Participant has proteinuria defined as > 1+; approximately 30 mg/dl.
26. Clinically significant abnormality on ECG
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