Home-based Progressive Resistance Exercise to Enhance Physical Performance of Older Adults With Possible Sarcopenia

Sarcopenia Clinical Trial

Official title:

Home-based Progressive Resistance Exercise to Enhance Physical Performance of Older Adults With Possible Sarcopenia

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04851262
• Other study ID #: UW20-868
• Status: Active, not recruiting
• Phase: N/A
• Start date: April 28, 2021
• Est. completion date: December 31, 2024

Study information

• Verified date: December 2023
• Source: The University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The overall aim of the proposed project is to improve muscle strength in older adults with possible sarcopenia by promoting home-based progressive resistance exercise. The target population for health talks is community-dwelling older adults. A Three monthly home-visits and weekly phone calls will be made. A waitlist randomised controlled trial will be conducted to evaluate effectiveness, and qualitative feedback will be collected from participants. A pilot study will be conducted first.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 42
• Est. completion date: December 31, 2024
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 89 Years

Eligibility

The inclusion criteria are:

• Aged 65-89;
• Possible sarcopenia (defined by AWGS 2019);
• No cognitive impairment (Abbreviated Mental Test score =8); and
• No communication problems.

The exclusion criteria are:

• having engaged in a structured exercise programme in the past 6 months or planning to do so within the intervention period;
• mobility-limiting injury of the hands or lower limbs, surgery or hospitalisation within the intervention period;
• contraindications such as musculoskeletal/cardiorespiratory disorders, or any advanced diseases that inhibit them from exercising.

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Behavioral:
• Exercise
The intervention is to be taught by fitness trainer at the participants' home at the start of each phase. The exercise progression model for older adults recommended by the American College of Sports Medicine, which emphasise gradual increments in training load and systematically alter one or more programme components, will be adopted.

Locations

Country	Name	City	State
Hong Kong	Community	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
The University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change in handgrip strength at 12 weeks from baseline	Measured by a spring-type dynamometer, higher value indicates better performance	12 weeks after baseline
Other	Change in handgrip strength at 24 weeks from baseline	Measured by a spring-type dynamometer, higher value indicates better performance	24 weeks after baseline
Other	Status of possible sarcopenia at 12 weeks from baseline	Indicated by 5-time chair stand test =12 second, or men and women with <28 kg and <18 kg strength	12 weeks after baseline
Other	Status of possible sarcopenia at 24 weeks from baseline	Indicated by 5-time chair stand test =12 second, or men and women with <28 kg and <18 kg strength	24 weeks after baseline
Other	Sarcopenia risk score at 12 weeks from baseline	Measured by SARC-CalF, which is a combination of SARC-F questionnaire and calf circumference, a cut of of >=11 indicates high risk	12 weeks after baseline
Other	Sarcopenia risk score at 24weeks from baseline	Measured by SARC-CalF, which is a combination of SARC-F questionnaire and calf circumference, a cut of of >=11 indicates high risk	24 weeks after baseline
Primary	Change in lower-limb muscle strength at 12 weeks from baseline	Measured by Short Physical Performance Battery (SPPB), higher score indicates better performance	12 weeks after baseline
Secondary	Change in lower-limb muscle strength at 24 weeks from baseline	Measured by Short Physical Performance Battery (SPPB), higher score indicates better performance	24 weeks after baseline