Creatine-Guanidinoacetic Acid Supplementation for Sarcopenia (CREGAAS)

Sarcopenia Clinical Trial

— CREGAAS  

Official title:

The Effects of 6-month Supplementation With Creatine and Guanidinoacetic Acid on Biomarkers of Sarcopenia in Elderly

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04652921
• Other study ID #: DS-04/2020
• Status: Completed
• Phase: N/A
• Start date: September 15, 2020
• Est. completion date: December 31, 2021

Study information

• Verified date: October 2022
• Source: University of Novi Sad, Faculty of Sport and Physical Education
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Sarcopenia-driven brain and muscle creatine deficit could be seen as a distinctive pathological facet of this condition, and this might be approached with targeted therapies in aim to restore creatine homeostasis in target tissues. Among potential therapeutic candidates, guanidinoacetate (GAA) appears recently as a direct precursor of creatine that may favorably upregulate muscle and brain creatine concentration. Interestingly, GAA-creatine mixture was found to be superior than creatine itself to effectively improves bioenergetics in the human brain and muscle in healthy humans, perhaps due to the unique transportability features of this combination. Here, we plan to evaluate does creatine-GAA supplementation affects various biomarkers of sarcopenia in elderly.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: December 31, 2021
• Est. primary completion date: December 15, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 90 Years

Eligibility

Inclusion Criteria:

• Age > 70 years
• Free of acute disorders

Exclusion Criteria:

• History of dietary supplement use during the past 4 weeks

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Dietary Supplement:
• Creatine-guanidinoacetic acid
A dietary supplement provided as powder dissolved in a glass of water

Other:
• Inulin
A dietary supplement provided as powder dissolved in a glass of water

Locations

Country	Name	City	State
Serbia	Applied Bioenergetics Lab at Faculty of Sport and PE	Novi Sad	Vojvodina

Sponsors (1)

Lead Sponsor	Collaborator
University of Novi Sad, Faculty of Sport and Physical Education

Country where clinical trial is conducted

Serbia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in muscular strength	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in muscle mass	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in muscle metabolites evaluated with MR spectroscopy	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in cognitive performance evaluated with Mini-Mental State Exam test	Baseline vs. 6 months	Baseline vs. 6 months post-intervention
Secondary	Change in serum creatine	Baseline vs. 6 months	Baseline vs. 6 months post-intervention