Sarcopenia Clinical Trial
Official title:
Exercise 'Prehabilitation': A Novel Intervention to Protect Against Disuse-induced Muscle Atrophy and Sarcopenia in the Old
Verified date | January 2020 |
Source | University of Birmingham |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Episodes of inactivity due to hospitalisation, as short as 5 days, are associated with rapid
muscle and strength loss in the elderly. The observed muscle loss with inactivity is likely
due to muscle anabolic resistance and increased breakdown rates of muscle tissue. This is of
great concern as the average hospital stay in the elderly is 5-6 days. Moreover, minor
illnesses not requiring hospitalisation generally require short-term periods of inactive
home-based recovery. The accumulation of repeated disuse events in older individuals
manifests in a chronic muscle anabolic resistance (i.e. the inability of muscle to respond to
anabolic stimuli such as exercise and nutrition) that may underpin the slow but devastating
process of age-related muscle loss.
It is our belief that strategies to promote muscle health in ageing and reduce healthcare
expenditure, should focus on alleviating muscle deterioration and anabolic resistance during
short-term disuse.
In this regard, we propose that resistance exercise (i.e. weight lifting) performed prior to
a disuse event (termed 'prehabilitation') may be sufficient to offset muscle loss in older
individuals. Thus, we suggest the potent effect of resistance exercise in older muscles may
prevent muscle loss during short-term disuse.
Status | Completed |
Enrollment | 20 |
Est. completion date | January 1, 2020 |
Est. primary completion date | October 1, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 65 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Males aged between 65-80 years - No history of structured resistance training within 10 years prior to study participation. - Generally good health as indicated by a thorough health questionnaire. - A score of =9 points on the Short Physical Performance Battery to assess lower extremity function. - Body Mass Index <30kg/m2 Exclusion Criteria: - Coagulation disorders - Myocardial infarction - Artery/vein disease - Hormone replacement therapy - Other chronic/systemic illnesses (i.e. renal failure, chronic obstructive pulmonary disease, cancer). - Undergone 2 or more muscle biopsies from each leg previously. - Received a stable isotope infusion in the last 3 years prior to study enrollment. |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Birmingham, School of Sport, Exercise and Rehabilitation Sciences | Edgbaston | West Midlands |
Lead Sponsor | Collaborator |
---|---|
University of Birmingham | Biotechnology and Biological Sciences Research Council, University of Nottingham |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Integrated myofibrillar protein synthesis rates | Myofibrillar protein synthesis rates will be measured during the prehabilitation and bed rest period in both the exercising and resting leg. | 2 years | |
Primary | Muscle mass via MRI | Muscle volume in the quadriceps will be assessed before and after bed rest using magnetic resonance imaging techniques | 2 years | |
Secondary | Muscle fibre properties | Via immunohistochemical staining procedures muscle fibre cross sectional area will be determined | 2 years | |
Secondary | Physical activity levels | Daily average time spent in sedentary, light, moderate or vigorous intensity activity using an accelerometer | 2 years | |
Secondary | Step-count | activity will be determined using accelerometry. Furthermore, step count will be Daily step-count assessed using a hip-worn pedometer | 2 years | |
Secondary | Plasma biomarkers of metabolic health | Blood markers - serum total cholesterol, serum high-density lipoprotein cholesterol, serum non-high-density lipoprotein cholesterol, total cholesterol, serum non-esterified fatty acids, serum triglycerides (units of measure for all - mmol/L) | 2 years | |
Secondary | Serum insulin | Via ELISA kits, resting insulin will be assessed using baseline plasma samples from before and after the bed rest period (pmol/l) | 2 years | |
Secondary | Intramuscular signaling via western blot | Western blots for phosphorylation of key anabolic and catabolic signaling proteins will be performed. | 2 years | |
Secondary | Gene expression | Search Results Web results Reverse transcription polymerase chain reaction (RT-PCR) will be performed to assess gene-expression of muscle anabolic and catabolic genes. |
2 years | |
Secondary | Dietary intake | Dietary intake will be assessed using 3-day weighed food diaries. | 2 years | |
Secondary | Body composition | Bioelectrical impedance analysis will be used to determine whole body fat and fat-free mass (units are % of total body mass for both fat and fat-free mass). | 2 years | |
Secondary | Leg strength | Estimated maximal leg strength will be determined for the leg extension and leg curl before and after the bed rest period | 2 years | |
Secondary | Height | measured using a stadiometer (cm) | 2 years | |
Secondary | Body weight | Measured using a digital weighing scale (kg) | 2 years | |
Secondary | Body Mass Index | Weight and height will be combined to report BMI in kg/m^2 | 2 years |
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