A Short-term Mixed Exercise for Sarcopenic Hospitalized Aged 80+ Years

Sarcopenia Clinical Trial

Official title:

Effectiveness of a Short-term Mixed Exercise Program for Treating Sarcopenia in Hospitalized Patients Aged 80 Years and Older

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04355299
• Other study ID #: 2019#611#
• Status: Completed
• Phase: N/A
• Start date: October 1, 2016
• Est. completion date: January 1, 2020

Study information

• Verified date: April 2020
• Source: West China Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Most previous clinical trials that addressed exercise for sarcopenic elderly subjects focused on community-dwelling older adults who were relatively healthy. There is a notable paucity of high-quality research investigating the effects and feasibility of exercise for hospitalized or institutionalized older people, who are generally frailer and more severe in functional impairment than those living in the community. Moreover, most reported exercise programs were of long-term duration, which typically lasted 3 to 6 months with two sessions per week. It remains unclear whether short-term exercise would be effective for treating sarcopenia. Therefore, the investigators aimed to assess the effectiveness of short-term exercise for treating sarcopenia in hospitalized older patients aged 80 years and over.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 121
• Est. completion date: January 1, 2020
• Est. primary completion date: December 30, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 80 Years to 102 Years

Eligibility

Inclusion Criteria:

1. aged =80 years;

2. being able to ambulate (assistance was acceptable);

3. being able to communicate and collaborate with the physiotherapist;

4. with sarcopenia defined by the AWGS criteria ;

Exclusion Criteria:

1. terminal illness;

2. uncontrolled heart failure;

3. myocardial infarction within the past three months;

4. uncontrolled respiratory failure;

5. bone fractures within the past three months;

6. acute pulmonary embolism;

7. major surgery within the past three months;

8. uncontrolled arrhythmia;

9. refusal to participate in this study.

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Behavioral:
• balance training
The training to improve balance is to work on the core muscle groups that help to maintain your posture.,and increase muscular strength.
• resistance training
Resistance training is a form of exercise that improves muscular strength and endurance. During a resistance training workout, you move your limbs against resistance provided by your body weight, gravity, bands, weighted bars or dumbbells.
• aerobic exercise
Aerobic exercise is any activity that gets your blood pumping and large muscle groups working. It's also known as cardiovascular activity.
• usual care
received usual care

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Yuxiang Liang

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The change of activities of daily living from the baseline to the end of the 2-week intervention	Basic activities of daily living (BADL) assessed by Barthel Index. The total score for Barthel Index ranges from 0 (worst) to 100 (best) points.	2 weeks
Secondary	The change of gait speed	Gait speed was measured using a 4-meter walking test.	2 weeks
Secondary	The change of handgrip strength	Handgrip strength was measured using a digital grip dynamometer	2 weeks
Secondary	The change of the score of Short Physical Performance Battery	The Short Physical Performance Battery (SPPB) is an objective assessment tool for evaluating lower extremity functioning in older persons. The total score for SPPB ranges from 0 (worst) to 12 (best) points.	2 weeks
Secondary	The change of the score of Timed Up and Go test	The Timed Up and Go test (TUG) is a simple test used to measure basic functional mobility and safety with mobility. The score for the TUG is the time consumption of the whole process. The longer time consuption indicates the more worse outcome.	2 weeks