Effects of Eccentric Training Intervention in Older Adults

Sarcopenia Clinical Trial

Official title:

Effects of Eccentric-based Training on Muscle Strength and Physical Function in Older Adults

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04099316
• Other study ID #: B-1705-397-004
• Status: Recruiting
• Phase: N/A
• Start date: July 20, 2017
• Est. completion date: October 31, 2019

Study information

• Verified date: September 2019
• Source: Seoul National University Bundang Hospital
• Contact: Jae-Young Lim, Ph.D.
• Phone: +821053900373
• Email: drlim1[@]snu.ac.kr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Sarcopenia leads to loss of muscle mass and muscle strength during the aging process. It has been reported that eccentric training has some positive effects on the preservation of eccentric strength, with less delayed onset muscle soreness (DOMS) in older groups, and lower metabolic costs.

Description:

This is prospective study. The goals of this study are to:

1. Examine the effects of eccentric training on physical function (gait speed, stair climb, chair stand) in older adults.

2. Examine the effects of eccentric training on muscle strength (Isometric strength, Isokinetic strength, power) in older adults.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 27
• Est. completion date: October 31, 2019
• Est. primary completion date: September 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 80 Years

Eligibility

Inclusion Criteria:

• Subjects who can agree voluntarily

• Older men/women: Age (60 - 80 yrs)

Exclusion Criteria:

• Uncontrolled hypertension

• Acute coronary syndrome

• Subjects who took drugs which can affects neuromuscular system

• Subjects who cannot agree voluntarily

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Device:
• Eccentric exercise
Eccentric exercise with Eccentron electronic device. Exercise intervention: The exercise intervention is performed to twice a week (Total 8 weeks). Exercise intensity is gradually increased to the number of times by divided into two stages (1-4 weeks; 1st stage),(5-8 weeks; 2nd stage).
• Conventional resistance exercise
Leg press exercise with leg press machine. Exercise intervention: The exercise intervention is performed to twice a week (total 8 weeks). Exercise intensity is gradually increased to the number of times by divided into two stages (1-4 weeks; 1st stage), (5-8 weeks; 2nd stage).

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University Bundang Hospital	Seongnam	Geyonggi

Sponsors (2)

Lead Sponsor	Collaborator
Seoul National University Bundang Hospital	National Research Foundation of Korea

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (17)

Cadore EL, Rodríguez-Mañas L, Sinclair A, Izquierdo M. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: a systematic review. Rejuvenation Res. 2013 Apr;16(2):105-14. doi: 10.1089/rej.2012.1397. Review. — View Citation

Chen TC, Tseng WC, Huang GL, Chen HL, Tseng KW, Nosaka K. Superior Effects of Eccentric to Concentric Knee Extensor Resistance Training on Physical Fitness, Insulin Sensitivity and Lipid Profiles of Elderly Men. Front Physiol. 2017 Apr 10;8:209. doi: 10.3389/fphys.2017.00209. eCollection 2017. — View Citation

Dias CP, Toscan R, de Camargo M, Pereira EP, Griebler N, Baroni BM, Tiggemann CL. Effects of eccentric-focused and conventional resistance training on strength and functional capacity of older adults. Age (Dordr). 2015 Oct;37(5):99. doi: 10.1007/s11357-015-9838-1. Epub 2015 Sep 15. — View Citation

Enoka RM. Eccentric contractions require unique activation strategies by the nervous system. J Appl Physiol (1985). 1996 Dec;81(6):2339-46. Review. — View Citation

Frontera WR, Hughes VA, Krivickas LS, Roubenoff R. Contractile properties of aging skeletal muscle. Int J Sport Nutr Exerc Metab. 2001 Dec;11 Suppl:S16-20. Review. — View Citation

Frontera WR, Reid KF, Phillips EM, Krivickas LS, Hughes VA, Roubenoff R, Fielding RA. Muscle fiber size and function in elderly humans: a longitudinal study. J Appl Physiol (1985). 2008 Aug;105(2):637-42. doi: 10.1152/japplphysiol.90332.2008. Epub 2008 Jun 12. — View Citation

Gault ML, Willems ME. Aging, functional capacity and eccentric exercise training. Aging Dis. 2013 Sep 25;4(6):351-63. doi: 10.14336/AD.2013.0400351. Review. — View Citation

Hanson ED, Srivatsan SR, Agrawal S, Menon KS, Delmonico MJ, Wang MQ, Hurley BF. Effects of strength training on physical function: influence of power, strength, and body composition. J Strength Cond Res. 2009 Dec;23(9):2627-37. doi: 10.1519/JSC.0b013e3181b2297b. — View Citation

LaStayo P, Marcus R, Dibble L, Wong B, Pepper G. Eccentric versus traditional resistance exercise for older adult fallers in the community: a randomized trial within a multi-component fall reduction program. BMC Geriatr. 2017 Jul 17;17(1):149. doi: 10.1186/s12877-017-0539-8. — View Citation

Lim JY. Therapeutic potential of eccentric exercises for age-related muscle atrophy. Integr Med Res. 2016 Sep;5(3):176-181. doi: 10.1016/j.imr.2016.06.003. Epub 2016 Jun 18. Review. — View Citation

Mueller M, Breil FA, Vogt M, Steiner R, Lippuner K, Popp A, Klossner S, Hoppeler H, Däpp C. Different response to eccentric and concentric training in older men and women. Eur J Appl Physiol. 2009 Sep;107(2):145-53. doi: 10.1007/s00421-009-1108-4. Epub 2009 Jun 20. — View Citation

Örer GE, Güzel NA, Arslan E. Recovery levels after eccentric and concentric loading in maximal force. J Phys Ther Sci. 2016 Jun;28(6):1743-7. doi: 10.1589/jpts.28.1743. Epub 2016 Jun 28. — View Citation

Raj IS, Bird SR, Westfold BA, Shield AJ. Effects of eccentrically biased versus conventional weight training in older adults. Med Sci Sports Exerc. 2012 Jun;44(6):1167-76. doi: 10.1249/MSS.0b013e3182442ecd. — View Citation

Roig M, Macintyre DL, Eng JJ, Narici MV, Maganaris CN, Reid WD. Preservation of eccentric strength in older adults: Evidence, mechanisms and implications for training and rehabilitation. Exp Gerontol. 2010 Jun;45(6):400-9. doi: 10.1016/j.exger.2010.03.008. Epub 2010 Mar 18. Review. — View Citation

Roig M, O'Brien K, Kirk G, Murray R, McKinnon P, Shadgan B, Reid WD. The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br J Sports Med. 2009 Aug;43(8):556-68. doi: 10.1136/bjsm.2008.051417. Epub 2008 Nov 3. Review. — View Citation

Symons TB, Vandervoort AA, Rice CL, Overend TJ, Marsh GD. Effects of maximal isometric and isokinetic resistance training on strength and functional mobility in older adults. J Gerontol A Biol Sci Med Sci. 2005 Jun;60(6):777-81. — View Citation

Váczi M, Nagy SA, Koszegi T, Ambrus M, Bogner P, Perlaki G, Orsi G, Tóth K, Hortobágyi T. Mechanical, hormonal, and hypertrophic adaptations to 10 weeks of eccentric and stretch-shortening cycle exercise training in old males. Exp Gerontol. 2014 Oct;58:69-77. doi: 10.1016/j.exger.2014.07.013. Epub 2014 Jul 23. — View Citation

* Note: There are 17 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Gait speed	An examiner used a stopwatch to time how long it took subjects to walk along a marked tape. The Kinect device was used to measure gait speed.	Change from baseline gaitspeed at 8 weeks
Primary	Stair climb	Subjects were measured on eight 17-cm stairs twice, requiring a step by step pattern, where the timer activated when the first contact was made at the first step and ended when the contact occurred at the last step before and after the 8 weeks of exercise training.	Change from baseline stair climb at 8 weeks
Primary	Chair stand	Subjects had to get up from a chair measuring 41 cm in height with a flat seat. Subjects were asked to stand up and sit down 5 times as quickly as possible with their arms folded across the chest. They stood up until full extension was observed at the trunk and lower limb joints, and returned to a seated position with their back fully supported at the back of the chair.	Change from baseline chair stand at 8 weeks
Secondary	Isokinetic knee strength	The isokinetic was measured using a baltimore therapeutic equipment (BTE) Primus RS (BTE Tech., Hanover, MD, USA). The subject performed a 60 degree per second knee flexion and extension five times. Each isokinetic contraction was performed through a full range of motion.Before each subject began the isokinetic test, the subject warmed up using a 50-60% knee extension/flexion once.; Isokinetic knee strength is measured in as peak torque achieved on an isokinetic dynamometer (BTE PrimusRS, BTE tech, MD, USA) at 60 degree per second.	Change from baseline isokinetic knee strength at 8 weeks
Secondary	Isometric knee strength	Isometric knee strength was measured using a baltimore therapeutic equipment (BTE) Primus RS (BTE Tech., Hanover, MD, USA). The subject was asked to sit on the treatment chair and a standard stabilization strap was placed on the upper ankle. The knee was kept at 90 degree flexion, and the foot was positioned in dorsi flexion. The subject's hands were placed on the edge of the side of the chair and the trunk, hips, and mid-thigh were stabilized in the chair by the straps.	Change from baseline isometric knee strength at 8 weeks
Secondary	Power	The test used same machine as the isometric and isokinetic tests. The ankle was placed in a neutral position, and the subjects performed a range of motion for 10 seconds, once. After the warm up, knee extension and flexion were performed as quickly as possible during a period of 10 seconds.; Isokinetic knee strength is measured in as peak torque achieved on an isokinetic dynamometer (BTE PrimusRS, BTE tech, MD, USA) at 60 degree per second.	Change from baseline power at 8 weeks