Cut-off Values of Muscle Thickness Ratio for Sarcopenia

Sarcopenia Clinical Trial

Official title:

Cut-off Values and Adjustments for Diagnosing Sarcopenia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03993405
• Other study ID #: GO 18/506-39
• Status: Completed
• Phase: N/A
• Start date: January 1, 2019
• Est. completion date: August 9, 2019

Study information

• Verified date: June 2019
• Source: Hacettepe University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The loss of muscle mass is one of the major diagnostic criteria for sarcopenia. Many methods are also used for the definition of sarcopenia. However there is no information about cut-off values in this respect in the literature. Therefore, the aim of this study is to determine the cut-off values of this ratio for confirming the diagnosis of sarcopenia.

Description:

Decreases in total skeletal muscle mass are accepted to be necessary for confirming the diagnosis of sarcopenia. Many methods are also used for the definition of sarcopenia.

However, ultrasound measurements has a high sensitivity and specify for confirming the diagnosis of sarcopenia. However there is no information about cut-off values in this respect in the literature. Therefore, the aim of this study is to determine the cut-off values of this ratio for confirming the diagnosis of sarcopenia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 292
• Est. completion date: August 9, 2019
• Est. primary completion date: July 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• To be a volunteer to participate

• To be an aged 18-90 years old.

Exclusion Criteria:

• Walking with assist device

• Having a visual deficits

• Having an undergone orthopedic surgery

• Having a cardiac pacemaker

• Having a hypothyroidism, diabetes mellitus, renal/hepatic failure

Related Conditions & MeSH terms

• Sarcopenia

Intervention

Other:
• Ultrasonographic evaluation
Ultrasonographic measurement is assessment method to diagnosis of sarcopenia

Locations

Country	Name	City	State
Turkey	Ozden Ozkal	Ankara

Sponsors (1)

Lead Sponsor	Collaborator
Hacettepe University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle thickness	Muscle thickness in millimeters by Ultrasound.	30 minutes
Primary	Skeletal muscle mass	Skeletal muscle mass will be evaluated by bioelectrical impedance analysis.The unit of measure is kg.	2 minutes
Secondary	Muscle strength	Muscle strength will be evaluated using an isokinetic dynamometer (Biodex Medical Systems, New York, USA). Knee and ankle muscle strength( flexion, extension, dorsiflexion and plantarflexion) will be evaluated. The unit of measure is Nm/kg.	15 minutes
Secondary	Peripheral strength	The peripheral (handgrip) strength will be measured with a dynamometer (JAMAR).Three measurements will be taken, whose average of the three measurements will be collected. The unit of measure is kg.	1 minutes
Secondary	Physical function	Physical function will be evaluated by short physical performance scale. The score of this scale range from 0 (worst performance) to 12 (best performance).	5 minutes
Secondary	Anthropometric assessments	Participants waist, hip and calf circumferences will be measured by tape measure. The unit of measure is centimeters.	5 minutes
Secondary	Balance	Timed up and go test evaluates dynamic balance of participants. The timed up and go test measures the time that a patient needs to stand up from a chair, walk a 3-m distance, come back and sit back on the chair.Timed up and go test measure is second. The lower values indicates the better balance.	1 minute
Secondary	Body mass index	Participants' weight and height will be evaluated by electronic weighing and tape measure, respectively. body mass index will be expressed in in kg/ m²	1 minute