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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03870425
Other study ID # BBH 140
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date April 9, 2019
Est. completion date February 28, 2022

Study information

Verified date November 2022
Source Bispebjerg Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The project examines over several days how the distribution pattern of dietary protein stimulate and affect the protein turnover of important proteins in the aging perspective, such as skeletal muscle proteins.


Recruitment information / eligibility

Status Completed
Enrollment 24
Est. completion date February 28, 2022
Est. primary completion date June 30, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 65 Years to 80 Years
Eligibility Inclusion Criteria: - Men and women - Between 65-80 years of age Exclusion Criteria: - BMI above 30 - Smokers - Vegetarians - Diabetes or other metabolic diseases - Medical treatment which affects protein turnover - Gastro-intestinal diseases, reduced kidney or liver function, or chronic inflammation diseases - Elevated blood-pressure or signs of atherosclerosis - More than 5 hours of regular exercise each week

Study Design


Intervention

Other:
Distribution pattern of dietary proteins (minced meat)
Study effect of an even or skewed distribution pattern of dietary protein

Locations

Country Name City State
Denmark Institute of Sports Medicine Copenhagen Copenhagen

Sponsors (1)

Lead Sponsor Collaborator
Bispebjerg Hospital

Country where clinical trial is conducted

Denmark, 

Outcome

Type Measure Description Time frame Safety issue
Primary Muscle protein synthesis Myofibrillar FSR measured by deuterated water technique, by which deuterium labeled alanine incorporation into myofibrillar muscle protein synthesis can be measured. 3 days
Primary Net protein balance Whole body net protein balance measured during 10 hours acute study. Measured by the application of stable amino acid labeled phenylalanine and tyrosine tracers, by which the protein synthesis, phenylalanine oxidation and protein breakdown can be calculated. 10 hours
Secondary D5-phenylalanine incorporation D5-phenylalanine incorporation into myofibrillar proteins. Dietary meat proteins are intrinsically labeled with D5-phenylalanine 3 days
Secondary Muscle protein synthesis Myofibrillar protein synthesis (%/hour) measured during 10 hours of the acute study. Calculated from the difference in D8-phenylalanine incorporation from the muscle biopsies taken at 2 hours and 12 hours into the stable amino acid tracer infusion. 10 hours
Secondary Protein synthesis Whole body protein synthesis (%/hour) measured during acute study, by the use of stabel amino acid tracer technique. 10 hours
Secondary Protein breakdown Whole body protein breakdown (%/hour) measured during acute study, by the use of stabel amino acid tracer technique. 10 hours
Secondary Phenylalanine oxidation Phenylalanine oxidation measured during acute study 10 hours
Secondary D5-phenylalanine appearance Plasma D5-phenylalanine enrichment after intake of D5-phenylalanine intrinsically labelled meat proteins 12 hours
Secondary Signaling pathways in skeletal muscle Intracellular signaling pathways related to protein turnover. Measured by Western blotting technique from the muscle tissue biopsies taken at 2 hours and 12 hours into the acute study. 10 hours
Secondary Plasma insulin Plasma insulin concentration during acute study 12 hours
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