Sarcopenia Clinical Trial
Official title:
Nutritional Supplementation and Muscle Health: A Pilot Study on Immune Function
The ability of older adults to improve their muscle strength through exercise training
appears related to how well their immune system functions. Thus, a nutritional supplement
which improves immune function could theoretically boost strength gained for older adults
from exercise. The purpose of this pilot study is to determine if a nutritional supplement
has any effect on immune function.
Veterans (age 60-80 yrs, N=12) be randomized in a double-blind placebo-controlled fashion to
consume supplement or placebo for four weeks. After two weeks of consumption, subjects will
be treated with a vaccine for tetanus, diphtheria, and pertussis. Blood will be drawn from
each subject before and after vaccination to determine the effects of the supplement on
immune response to vaccination. Additionally, subjects will undergo blood draw and muscle
biopsy before and after two weeks of supplementation to determine the effects of
supplementation on other measures of immune function (e.g. cytokine and growth factor
levels). This is an important issue due to the serious health consequences associated with
muscle loss in older adults and the need for improved strategies for rehabilitation.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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