Sarcopenia Clinical Trial
Official title:
Human Muscle Gene Expression Profiles in Young and Old Men
To reach the goals of living longer in better medical conditions, many countries reach the
same conclusion: new strategies have to be developed to avoid, or at least limit, the
effects of age; this requires a better knowledge of the mechanisms of aging. Our project
focuses on the loss of muscle mass associated with aging, called sarcopenia. Sarcopenia
unavoidably leads to impaired mobility and poor balance, which contributes to loss of
functional autonomy and to increased prevalence for severe falls. Skeletal muscle also plays
a central role as a reserve for energy and amino acids. Hence, sarcopenia further triggers
severe side metabolic effects such as frailty among elderly persons. The precise mechanisms
of muscle aging are still mostly unknown, although many theories have been proposed.
The present study aims at better understanding the mechanisms of skeletal muscle loss
associated with aging. Using muscle biopsies from young and old subjects, the differential
expression profiles of mRNA will be obtained through chips that will evaluate more than
39000 transcripts. On the same samples, proteomic analyses will involve two complementary
approaches: (1) bidimensional electrophoresis (2DGE) coupled to mass spectrometry
(MALDI-ToF) for dominant proteins; (2) Western-blot (more than 800 antibodies) targeting
regulating proteins not detectable using 2DGE. Complementary histological studies
(immunohisto-fluorescence, confocal microscopy) will specify the localisation of the major
biomarkers in the muscle biopsies.
The results of that research will have applications in the medium term and will lead to
nutritional interventions to modulate specific metabolic pathways and improve the quality of
life in the elderly.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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