Sarcoma Clinical Trial
Official title:
Identification and Characterization of Molecular Markers in Musculoskeletal Tumors
The aim of the study is to improve the understanding of molecular mechanisms in the development and progression of musculoskeletal tumors. These tumors do have in general unfavorable prognosis and conventional treatments (e.g. surgery, radiotherapy or chemotherapy) could not enhance the prognosis of these patients during the last ten to fifteen years. Therefore the investigators chose a new way, as they try to identify markers on a genetic level, who ideally act as a basis to develop new treatment options.
To definitely asses such molecular markers in musculoskeletal tumors they have to be
identified in human patient samples with corresponding tumors, before molecular markers can
be validated in animal models. Just because these soft tissue and bone tumors are rare
(compared to breast and lung carcinomas), it is of great importance that samples from all
patients treated at Balgrist University Hospital are collected systematically und stored
correspondingly. Only like this valid statements can be done. Therefore the investigators
intent to collect tissue and blood samples from all patients who agree in participating in
the study. The samples will be taken during routine biopsies and operations. To compare tumor
tissue and healthy tissue it is also planed to take samples from tumor free patients who
undergo a knee replacement surgery. The investigators would store the surgical waste and
involve these samples in the analyzes.
Clinical data regarding diagnosis and examination findings, as well as tissue from biopsies
and surgeries will be collected prospectively. The tissue will be frozen in liquid nitrogen
according to standard procedures and stored until the molecular analyzes at the Laboratory of
Orthopedic Research at Balgrist University Hospital. The processing involves expression
analyzes such as polymerase chain reaction, Western Blot, micro arrays, immunohistochemistry
and tissue array. The DNA from the taken blood samples shall be compared with the DNA found
in the tumor.
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