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NCT01426945 Clinical Trial

Protein Expression in Samples From Young Patients With Rhabdomyosarcoma

Sarcoma Clinical Trial

Official title:
Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01426945
Other study ID # ARST11B3
Secondary ID COG-ARST11B3ARST
Status Completed
Phase N/A
First received August 31, 2011
Last updated May 17, 2016
Start date November 2011

Study information
Verified date May 2016
Source Children's Oncology Group
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.

PURPOSE: This research trial studies protein expression in samples from young patients with rhabdomyosarcoma.

Description:

OBJECTIVES:

- To measure the protein expression of candidate proteins in human rhabdomyosarcoma (RMS) tumor samples.

OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1, Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies. Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS) tumor stage, and RMS tumor subtype.

Recruitment information / eligibility
Status Completed
Enrollment 77
Est. completion date
Est. primary completion date May 2016
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility DISEASE CHARACTERISTICS:

- Tumor tissue samples from children with rhabdomyosarcoma (RMS) enrolled in the Children's Oncology Group clinical trials

- Alveolar rhabdomyosarcoma (ARMS)

- Embryonal rhabdomyosarcoma (ERMS)

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

Intervention

Genetic:
• protein expression analysis

Other:
• immunohistochemistry staining method

• laboratory biomarker analysis

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Children's Oncology Group National Cancer Institute (NCI)

Outcome
Type Measure Description Time frame Safety issue
Primary RMS protein expression profile No
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