Sarcoma Clinical Trial
Official title:
Treatment of Classical Kaposi Sarcoma With Nicotine Dermal Patch: A Phase II Trial
RATIONALE: Nicotine may stimulate the immune system to kill Kaposi's sarcoma cells.
PURPOSE: This phase II trial is studying the side effects and how well the nicotine skin
patch works in treating patients with Kaposi's sarcoma.
OBJECTIVES:
- Evaluate the toxicity and efficacy of transdermal nicotine applied to lesions in
patients with classic Kaposi's Sarcoma.
OUTLINE: This is a double-blind, placebo-controlled study.
Patients apply a nicotine dermal patch to a selected lesion and a placebo patch to the other
lesion, replacing the same type of fresh patch every other day, during the first 2 weeks,
increasing the nicotine dose in week 3 and again in week 5 for a total of 15 weeks in the
absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A total of 24 patients will be accrued for this study.
;
Masking: Double-Blind, Primary Purpose: Treatment
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