Sarcoma Clinical Trial
Official title:
Phase II Trial of VAC2.2/VA Therapy for Low-Risk B Group Patients With Rhabdomyosarcoma
RATIONALE: Drugs used in chemotherapy, such as vincristine, dactinomycin, and
cyclophosphamide, work in different ways to stop the growth of tumor cells, either by
killing the cells or by stopping them from dividing. Giving more than one drug (combination
chemotherapy) may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving vincristine, dactinomycin, and
cyclophosphamide together works in treating patients with embryonal rhabdomyosarcoma.
OBJECTIVES:
- Determine the progression-free survival rate in patients with low-risk embryonal
rhabdomyosarcoma treated with intensive chemotherapy comprising vincristine,
dactinomycin, and cyclophosphamide followed by vincristine and dactinomycin.
OUTLINE: Patients receive vincristine IV, dactinomycin IV, and cyclophosphamide IV on day 1.
Treatment repeats every 21 days for 8 courses in the absence of disease progression or
unacceptable toxicity. Patients then receive vincristine IV and dactinomycin IV on day 1.
Treatment repeats every 3 weeks for 8 courses in the absence of disease progression or
unacceptable toxicity.
PROJECTED ACCRUAL: A total of 41 patients will be accrued for this study.
;
Masking: Open Label, Primary Purpose: Treatment
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