Sarcoma Clinical Trial
Official title:
A Phase II Study of Navelbine (Vinorelbine) In Children With Recurrent Or Refractory Malignancies
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of vinorelbine in treating children with
recurrent or refractory cancer.
OBJECTIVES: I. Determine the response rate of children with recurrent or refractory
malignancies treated with vinorelbine. II. Assess the toxic effects of this drug in these
children.
OUTLINE: Patients receive vinorelbine IV over 6-10 minutes weekly on weeks 1-6. Treatment
repeats every 8 weeks for a total of 10 courses in the absence of disease progression or
unacceptable toxicity. Patients are followed every 4 months for 2 years, every 6 months for
1 year, and then annually thereafter.
PROJECTED ACCRUAL: A maximum of 100 patients will be accrued for this study within 2 years.
;
Primary Purpose: Treatment
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