TK216 in Patients With Relapsed or Refractory Ewing Sarcoma

Status Terminated

Clinical Trial Summary

Ewing sarcoma is characterized by genomic rearrangements resulting in over-expression of ets family transcription factors driving tumor progression. TK216 is designed to inhibit this effect by inhibiting downstream effects of the EWS-FLI1 transcription factor. This study is a first in human study of TK216 in subjects with Ewing sarcoma. The study is designed to establish initial safety and efficacy data in monotherapy and in combination with vincristine to assess the potential of TK216 for further development.

Clinical Trial Description

The study has been expanded to explore single agent TK216 for longer treatment duration. Approximately 26 patients will be enrolled in this Cohort. ;

Study Design

Related Conditions & MeSH terms

Neuroectodermal Tumors, Primitive, Peripheral
Sarcoma
Sarcoma, Ewing

Clinical Trial Details

NCT number	NCT02657005
Study type	Interventional
Source	Oncternal Therapeutics, Inc
Contact
Status	Terminated
Phase	Phase 1/Phase 2
Start date	August 2016
Completion date	June 2022

View Details

See also
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