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Salivary Gland Diseases clinical trials

View clinical trials related to Salivary Gland Diseases.

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NCT ID: NCT06240806 Completed - Dry Mouth Clinical Trials

Efficacy of Manuka Honey Oral Rinse in Treatment of Xerostomia

Start date: December 1, 2023
Phase: N/A
Study type: Interventional

Xerostomia causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food thus may affect the individual's quality of life, therefore this study aimed to evaluate the clinical effectiveness of Manuka honey mouth rinse using the subjective dry mouth score, and patient satisfaction as primary objectives and to assess the effect of Manuka honey on the salivary flow rate, and objective dry mouth score as secondary objectives.

NCT ID: NCT05346341 Completed - Clinical trials for Salivary Gland Diseases

Evaluation of the Effect of Minimally Invasive Procedures Used in Management of Salivary Ductal Pathologies on Patients' Symptomatology and Gland Function

Start date: February 11, 2021
Phase: N/A
Study type: Interventional

Aim of the current study was to evaluate the minimally invasive techniques in the management of salivary gland ductal pathologies

NCT ID: NCT05151029 Not yet recruiting - Clinical trials for Salivary Gland Diseases

Elastography in the Evaluation of Major Salivary Gland Lesions

Start date: September 1, 2022
Phase:
Study type: Observational

2.2 Aim(s) of the Research (50 words max): To investigate the diagnostic accuracy of Sonoelastography in the evaluation of major salivary gland lesions using histopathology as gold standard.

NCT ID: NCT04507646 Completed - Clinical trials for Salivary Gland Diseases

The Effectiveness of Auricular Acupuncture on Improving Secretion of Saliva Among Institutional Older Population

Start date: August 26, 2020
Phase: N/A
Study type: Interventional

The study aims to examine the effect of auricular acupuncture on improving oral health in older population. The hypothesis of this study is that older people receiving auricular acupuncture can increase salivary secretion. By identifying the effectiveness of auricular acupuncture can increase salivary secretion; suitable care can be suggested to improve oral health in older population living in long-term institutions.

NCT ID: NCT03893812 Not yet recruiting - Clinical trials for Salivary Gland Diseases

Color Doppler and Mri Diffusion in Major Salivary Gland Masses

Start date: October 2019
Phase:
Study type: Observational

This study intend to evaluate the combined value of ADC and COLOR DOPPLER in differentiating benign and malignant salivary gland tumors in comparison to histopathological findings and its use in preoperative prediction of benign and malignant masses.

NCT ID: NCT03874572 Active, not recruiting - Xerostomia Clinical Trials

Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth

MESRIX-SAFETY
Start date: March 18, 2019
Phase: Phase 1
Study type: Interventional

An investigator-initiated, non-randomized, open label study to investigate the safety, feasibility and tolerability of intraglandular injection of allogeneic mesenchymal stem/stromal cells (MSCs) into the submandibular and parotid glands of the patients with radiation-induced hyposalivation and xerostomia after radiation for a oropharyngeal squamous cell carcinoma

NCT ID: NCT03746730 Not yet recruiting - Clinical trials for Salivary Gland Diseases

Role of US,Doppler in Major Salivary Gland Diseases

Start date: December 1, 2018
Phase:
Study type: Observational

To evaluate the role of gray scale and Doppler ultrasound in characterizing of parotid and submandibular gland lesions in comparison to biopsy if needed

NCT ID: NCT02883140 Completed - Clinical trials for Non Tumor Salivary Gland Diseases of the Submandibular Glands

Imaging Study of 3D-CBCT Sialography and MRI Sialography in Non Tumor Salivary Diseases

PIGS
Start date: June 23, 2016
Phase:
Study type: Observational

Non tumor salivary gland diseases are common and include sialadenitis, sialadenosis, stones, stricture and ductal dilatation, anatomical abnormalities. A radiological examination is required in order to sign the diagnosis, locate precisely the lesions and define the therapeutic strategy. Cone beam computerized tomography (CBCT), because of its accessibility and the possibilities it offers in terms of image processing, is a potential alternative to the conventional sialography and to the MRI sialography, considered as a gold standard procedure. Our comparative study, aims to evaluate the diagnostic performance of the 3D-CBCT sialography compared to MRI sialography, in patients with non tumor ductal salivary diseases.

NCT ID: NCT02327884 Recruiting - Healthy Volunteer Clinical Trials

Characterization of Diseases With Salivary Gland Involvement

Start date: April 3, 2015
Phase:
Study type: Observational

Background: - Salivary glands in and around the mouth and throat make saliva. Salivary gland disorders can affect a person s quality of life. Studying people who have a disease that affects their salivary gland(s) may teach researchers about the disorders and their genetics. Objectives: - To study salivary gland diseases and disorders. To collect data and samples from people with salivary gland problems and their relatives. Eligibility: - People more than 4 years old who have or are suspected to have a disease involving salivary glands. - Their relatives more than 4 years old. - Healthy volunteers 18 years or older. Design: - Participants may be screened with: - Medical history - Physical exam - Blood and urine tests - General oral and dental history and exam - Saliva collection - Eye exam and test for dry eyes - Health questionnaires (adults) - Biopsy of some minor salivary glands. A small incision will be made on the inside of the lower lip and several tiny salivary glands will be removed. - Participants will have 2 3 visits. These may include: - Repeats of some screening tests - Ultrasounds of some glands. Researchers will put some gel on the face, then press on it with a smooth wand. - Adults may have other biopsies - A small catheter inserted into the opening of the parotid gland duct on the inside of the cheek. A saline solution (in a syringe) will fill the duct. - Swishing a saltwater solution in the mouth for 10 seconds and then spitting into a cup - Scrapings collected from teeth, tongue, and cheeks

NCT ID: NCT02068846 Completed - HIV Clinical Trials

BK Virus in Salivary Gland Disease: Treating the Potential Etiologic Agent

Start date: April 2014
Phase: Phase 3
Study type: Interventional

The purpose of this study is to analyze BK viral infection in salivary gland diseases; specifically, to determine a definitive relationship between BK Virus and HIV associated salivary gland disease (HIVSGD). Participants are adults HIV+SGD+ who will be randomized 1:1 to receive BK Virus antiviral (ciprofloxacin) or placebo for 28 days. Salivary function/protein secretion will be correlated with BK polyomavirus titers. It is expected that patients with HIV+SGD+ will have elevated oral BK polyomavirus viral loads and will benefit from Ciprofloxacin.