Salivary Gland Cancer Clinical Trial
Official title:
A Multicenter Phase I/II Trial of a Novel MDM2 Inhibitor (APG-115) in p53 Wild-type Salivary Gland Carcinoma
This is a phase I/II trial to evaluate the efficacy of APG-115 +/- Carboplatin for the treatment p53 wild-type malignant salivary gland cancer. Part 1 consisted of 2 arms, arm A (APG-115 monotherapy) and arm B (APG-115 + Carboplatin) and was terminated early. Part 2 is a single arm study (APG-115 monotherapy).
The current single arm study design was originally part of a study with a parallel arm given combination APG-115 + Carboplatin. In the initial phase of that previous iteration, the combination arm was closed early for issues related to tolerability of the combination therapy. This study will continue as a single arm, monotherapy alone, Phase I/II study as approved by the UM Institutional Review Board as of June 2021. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT03729297 -
Cabozantinib in Advanced Salivary Gland Cancer Patients
|
Phase 2 | |
Active, not recruiting |
NCT01969578 -
Androgen Deprivation Therapy in Advanced Salivary Gland Cancer
|
Phase 2 | |
Completed |
NCT01703455 -
Activity of Sorafenib in Salivary Gland Cancer
|
Phase 2 | |
Recruiting |
NCT04140526 -
Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT05010629 -
9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma
|
Phase 2 | |
Completed |
NCT03319641 -
PSMA-PET Imaging for Advanced ACC/SDC
|
N/A | |
Recruiting |
NCT02012699 -
Integrated Cancer Repository for Cancer Research
|
||
Recruiting |
NCT04028479 -
The Registry of Oncology Outcomes Associated With Testing and Treatment
|
||
Recruiting |
NCT05483374 -
The Head and Neck Registry of the European Reference Network on Rare Adult Solid Cancers
|
||
Completed |
NCT04291300 -
Lutetium-177-PSMA Radioligand Therapy in Advanced Salivary Gland Cancer Patients
|
Phase 2 | |
Active, not recruiting |
NCT03172624 -
Study of Nivolumab Plus Ipilimumab in Patients With Salivary Gland Cancer
|
Phase 2 | |
Completed |
NCT00509002 -
Iressa Study in Patients With Salivary Gland Cancer
|
Phase 2 | |
Active, not recruiting |
NCT05008237 -
Weekly Docetaxel Plus Cisplatin as First-line Chemotherapy in Metastatic Salivary Gland Cancer Patients : a Multicenter Phase II Study
|
Phase 2 | |
Recruiting |
NCT03360890 -
Pembrolizumab With Chemotherapy for Poorly Chemo-responsive Thyroid and Salivary Gland Tumors
|
Phase 2 | |
Not yet recruiting |
NCT05898373 -
Vedicitumomab Alone or in Combination for the Treatment of Locally Advanced or Metastatic SDC
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT02069730 -
A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of Genes
|
N/A | |
Recruiting |
NCT04209660 -
Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers
|
Phase 2 | |
Completed |
NCT01344356 -
Stereotactic Body Radiotherapy for Head and Neck Tumors
|
Phase 4 | |
Completed |
NCT03602079 -
Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT06091878 -
Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers
|