The Effect of Chewing the Tapioca Pearls in Bubble Tea Drinks

Saliva Clinical Trial

Official title:

Quality Improvement of Saliva by Chewing Tapioca Pearls in Bubble Tea Drinks

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04670341
• Other study ID #: FKGUGM1
• Status: Completed
• Phase: N/A
• Start date: September 17, 2020
• Est. completion date: October 17, 2020

Study information

• Verified date: December 2020
• Source: Gadjah Mada University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Bubble tea drinks contain tea and tapioca pearls. Chewing tapioca pearls in bubble tea drinks may increase salivary components. Because of its proteins, inorganic components, and enzymes, saliva plays an important role in the body's defense against bacteria and viruses. This study aims to analyze the effect of chewing the tapioca pearls in bubble tea drinks on salivary C-reactive protein (CRP) and calcium (Ca) levels.

Description:

Sixty saliva samples were collected from 15 subjects. The inclusion criterion was 18-25 years of age. The exclusion criteria were receiving medication, using dentures, a history of dry mouth, smoking and systemic disease. In the first week of the experiment, subjects drank bubble tea as the intervention group. In the second week, the same subjects drank tea without pearls as the control group. Each subject drank the bubble tea for 5 minutes per day over 3 days. Saliva samples were collected on the first day before bubble tea consumption (pretest) and on the third day after tea consumption (posttest). Saliva collection was performed in the morning (09:00 a.m.-12:00 p.m.) for 1 minute. Salivary CRP levels were measured using an ELISA kit, and Ca levels were determined using a test kit.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: October 17, 2020
• Est. primary completion date: October 17, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 25 Years

Eligibility

Inclusion Criteria:

• good Oral Hygiene Index-Simplified (OHI-S) score

Exclusion Criteria:

• taking medication

• a history of dry mouth

• smoking

• systemic disease

Related Conditions & MeSH terms

• Saliva

Intervention

Other:
• chewing tapioca pearls in bubble tea drinks
Saliva was collected on the first day before bubble tea consumption (pretest) and on the third day after bubble tea consumption (posttest); collection was conducted in the morning (09:00 a.m.-12.00 p.m.).
• drink tea without chewing tapioca pearls
Saliva was collected on the first day before drink tea without tapioca pearl (pretest) and on the third day after tea consumption (posttest); collection was conducted in the morning (09:00 a.m.-12.00 p.m.).

Locations

Country	Name	City	State
Indonesia	Faculty of Dentistry, Universitas Gadjah Mada	Yogyakarta

Sponsors (1)

Lead Sponsor	Collaborator
Gadjah Mada University

Country where clinical trial is conducted

Indonesia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Salivary C-reactive protein (CRP) level	Salivary CRP level was measured on the first day before chewing tapioca peals in the bubble tea drinks and drink tea. Salivary CRP level was measured on the third day after drink bubble tea and tea without tapioca pearls	3 days
Secondary	Calcium (Ca) level	Ca level was measured on the first day before chewing tapioca peals in the bubble tea drinks and drink tea. Ca level was measured on the third day after drink bubble tea and tea without tapioca pearls	3 days

External Links

•   Elevated salivary C-reactive protein levels are associated with active and passive smoking in healthy youth: A pilot study