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Clinical Trial Summary

This study aims to further define and characterize imaging findings of possible sacroiliitis in Crohn's Disease patients by recalling subjects who had findings of possible sacroiliitis on prior MRE and assess the natural history and outcome of these cases by using standard magnetic resonance imaging (MRI) and x-ray of the sacroiliac joints.


Clinical Trial Description

When axial spondyloarthritis (SpA) occurs in Crohn's disease (CD) is an important clinical and research question that has not been fully answered. Magnetic resonance enterography (MRE), routinely obtained in Crohn's disease (CD) patients, can be utilized to assess sacroiliac joints (SIJ); currently published literature shows that it could be a valuable tool to detect active inflammation of sacroiliitis in CD patients. Only a small fraction of CD patients with MRE evidence of sacroiliitis is referred to rheumatologists for further evaluation. The proposed project aims to further define MRE features of sacroiliitis in CD by recalling subjects who had prior positive findings and assess the natural history and outcome of these cases by standard magnetic resonance imaging (MRI) of sacroiliac joints and SIJ X-ray. 37 CD subjects who were already found to have sacroiliitis in the previous MRE study will be recalled. Subjects will undergo standard MRI of SIJ, plain X-ray of SIJ and the rheumatologist will obtain detailed history and examine patients for evaluation of possible axial SpA. Other details pertaining to CD, CD therapy and activity, will also be obtained to help clarify a correlation between CD and axial SpA. This pilot study will allow better characterization of imaging features of sacroiliitis on MRE, provide useful information on clinical significance of these lesions in CD patients, and potentially establish MRE as a screening tool for early detection of sacroiliitis in CD patients. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05203926
Study type Interventional
Source NYU Langone Health
Contact Fardina Malik, MD
Phone 646-501-7400
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date March 2022
Completion date December 2022

See also
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Active, not recruiting NCT03122119 - Effectiveness of Ultrasound Guided Platelet Rich Plasma Injections in the Sacroiliac Joint Phase 4
Completed NCT02098694 - Physiotherapy-led Outpatient Clinic for Patients With Spondyloarthritis N/A
Completed NCT01673633 - Sacroiliitis in Systemic Sclerosis N/A
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Completed NCT03834480 - Intraartecular Platelet Rich Plasma for Sacroiliitis N/A
Not yet recruiting NCT05276024 - Evaluation of the iFuse Bedrock Technique in Association With Posterior Lumbosacral Fusion With Iliac Fixation.