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S-ketamine clinical trials

View clinical trials related to S-ketamine.

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NCT ID: NCT05922605 Recruiting - Pediatrics Clinical Trials

Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias

Start date: June 20, 2023
Phase: Phase 4
Study type: Interventional

Caudal analgesia with ropivacaine is commonly used in sub-umbilical pediatric surgery. However, increasing the dosage of ropivacaine has not been found to prolong the action significantly while complications will be serious. Ketamine as an additive to caudal administration had been shown to prolong the duration of postoperative analgesia, while the analgesic effectiveness of S-ketamine, the S(+)-enantiomer of ketamine with less possibility to induce psychomotor disturbances, is not clear. In this prospective randomized double-blind clinical trial , the investigators aimed to study the effect of S-ketamine as additive on the duration of caudal analgesia.

NCT ID: NCT05299866 Recruiting - Cesarean Section Clinical Trials

The Effect of S-ketamine Combined With Sufentanil for Postoperative Analgesia in Patients Following Cesarean Section

Start date: April 12, 2022
Phase: Phase 4
Study type: Interventional

This randomized controlled trial is designed to investigate the effect of low-dose of S-ketamine combined with sufentanil for postoperative patient-controlled intravenous analgesia in patients following cesarean section.

NCT ID: NCT05242081 Recruiting - Clinical trials for Opioid Use, Unspecified

Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol

Start date: July 2022
Phase: N/A
Study type: Interventional

The purpose of this study was to observe the effects of opioid-free anesthesia with S-ketamine on postoperative analgesia and perioperative hemodynamics in short surgical operations, and to explore the effects of S-ketamine on postoperative awakening time and extubation time, nausea and vomiting, hypoxemia, and delirium.

NCT ID: NCT04964219 Recruiting - Clinical trials for Postoperative Analgesia

Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery

Start date: February 8, 2022
Phase: Phase 4
Study type: Interventional

Despite opioid-based multimodal analgesia, moderate-to-severe pain remains a big problem in patients following multi-segment spinal fusion. As a N-methyl-D-aspartate receptor antagonist, S-ketamine has prominent analgesic effects through activating receptors both in the brain and in the spinal cord, inhibiting the excitatory postsynaptic potential, and thus blunting nociception transmission. This randomized controlled trial is designed to investigate whether perioperative S-ketamine infusion can decrease pain intensity after major spine fusion surgery.

NCT ID: NCT04834427 Enrolling by invitation - Postoperative Pain Clinical Trials

Safety and Efficacy Evaluation of S (+) - Ketamine in Children

Start date: April 20, 2022
Phase: Phase 4
Study type: Interventional

A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in children in perioperative settings.

NCT ID: NCT04791059 Completed - Dexmedetomidine Clinical Trials

Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Postoperative Analgesia

Start date: April 9, 2021
Phase: Phase 4
Study type: Interventional

Scoliosis correction surgery is followed with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and even drug tolerance. S-ketamine is the pure dextrorotatory enantiomer of ketamine with stronger analgesic effect and less side effects, but mental side effects is a major concern. Dexmedetomidine can be used as an analgesic supplement; it also improves sleep quality in postoperative patients. We hypothesize that low-dose ketamine and dexmedetomidine in combination with opioids may have synergistic effect in analgesia and reduce drug-related side effects. This study aims to explore the effect of low-dose of S-ketamine and dexmedetomidine in combination with opioids for postoperative patient-controlled intravenous analgesia in patients following scoliosis correction surgery.