Role of Vagal Tone in Rumination Syndrome

Rumination Clinical Trial

Official title:

Rumination Syndrome: Role of Vagal Tone and Effect of Respiratory Manoeuvres on Severity and Frequency of Rumination

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03912636
• Other study ID #: 19/ss/0054
• Status: Completed
• Phase: N/A
• Start date: May 1, 2019
• Est. completion date: March 31, 2020

Study information

• Verified date: April 2022
• Source: Queen Mary University of London
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Rumination syndrome is a condition in which people repeatedly and unintentionally regurgitate undigested or partially digested food from the stomach, rechew it, and then either re-swallow it or spit it out. The mechanism of the disease is not well understood. The investigators believe that discomfort in the stomach during and immediately after meals may be an important factor for this disease. The reason for such discomfort can be due to an alteration of nervous regulation of the stomach. The investigators can study the nervous regulation that affects the stomach and other parts of the body by analysing in detail an electrocardiogram that is performed continuously for several hours. From this analysis, The investigators can study a parameter called cardiac vagal tone (CVT).

Diaphragmatic breathing (DiaB) is a respiratory exercise, in which people mainly move their abdomen to breath. DiaB is a common treatment for rumination syndrome. Patients doing DiaB can reduce the number of rumination episodes. The mechanism by which DiaB improves rumination is unknown. There is another type of breathing called slow deep breathing (SlowDB), in which people mainly breathe with their chest. SlowDB is used as a therapy for increased pain in the food pipe (oesophagus) and it might also be effective on rumination syndrome. The investigators believe that both DiaB and SlowDB can improve rumination, by modifying the nervous control of the stomach (that the investigators can monitor by measuring continuously cardiac vagal tone (CVT)). The aims of the study are to investigate the association between gastric discomfort during a meal, CVT variations (measured with the electrocardiogram during the meal) and the severity of rumination episodes. The investigators will also study how DiaB and SlowDB can modify this variable during the test. In a second step, The investigators will assess the clinical effect of respiratory exercises (DiaB and SlowDB) on the severity and frequency of regurgitations in patients diagnosed with rumination syndrome.

Method This research consists of two separate studies.

1. Study1 (to investigate the mechanism of rumination syndrome) 10 healthy volunteers and 10 rumination patients will join Study1 on 3 separate days. On each visit, the investigators will place electrocardiogram sensors and a belt that can measure the thorax or abdominal movement. All subjects will get instructions to perform SlowDB or DiaB, answer some questionnaires, eat the test meal, perform normal breathing/DiaB/SlowDB for 15 minutes, and stay quietly on the chair for 3 hours.

2. Study 2 (to assess the effect of DiaB and SlowDB on rumination syndrome) 10 patients with rumination syndrome will join Study 2. On the first visit, subjects will have the test meal, answer the symptom questionnaire 1 hour after the meal, and learn how to perform either DiaB or SlowDB. After the first visit, subjects perform DiaB or SlowDB during 15 minutes after every meal for 4 weeks. On the second visit, subjects will have the test meal, answer the symptom questionnaire 1 hour after the meal, and learn how to perform the other respiratory exercise. After a 2-week break, subjects will perform the other respiratory exercise for the next 4 weeks. On the last visit, subjects will have the test meal and answer the symptom questionnaire 1 hour after the meal.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: March 31, 2020
• Est. primary completion date: March 31, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Healthy volunteers (HVs)

• 18-65 years old

• No history of any gastrointestinal (GI) symptoms in the 3 months prior to the study.

• No medications 3 months prior to the study

2. Rumination patients

• 18-65 years old

• Fulfilling ROME IV clinical criteria for rumination

• Confirmed rumination syndrome by High Resolution Impedance Monometry within 12 months prior to the study

• No history of performing DiaB as a therapy for rumination syndrome.

• No medications which may affect vagal tone, the number of rumination episodes and GI motility 3 months prior to the study. (i.e. opioids, Baclofen , anticholinergics drugs, prokinetics, beta-blockers)

Exclusion Criteria:

• Pregnant or lactating women

• History of GI surgeries apart from appendectomy

• Alcohol or substance abuse, mental health illness

• Inability to obtain informed consent

• Non-fluent English speakers

• Participants with food intolerances or allergies that would not be able to take in the test meal (McDonalds Big Mac meal)

• Major comorbidities such as significant cardiac/pulmonary disease, cancer, life-threatening conditions or other life-limiting conditions

• Evidence of relevant organic diseases. (in endoscopy, CT.)

• Evidence of major esophageal motility disorders (Chicago classification ver3.0) (21)

• Known allergy to ECG electrodes or latex

• History of diabetes

Related Conditions & MeSH terms

• Feeding and Eating Disorders of Childhood
• Rumination

Intervention

Behavioral:
• Diaphragmatic breathing
Subjects will perform Diaphragmatic breathing after the test meal.
• Deep Slow Breathing
Subjects will perform Deep Slow Breathing after the test meal.
• Normal breathing
Subjects will perform Normal Breathing (as a control) after the test meal as a control.

Locations

Country	Name	City	State
United Kingdom	Wingate Institue	London

Sponsors (1)

Lead Sponsor	Collaborator
Queen Mary University of London

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison of changes in cardiac vagal tone (CVT) calculated from R-R intervals in electrocardiogram between healthy volunteers and rumination patients in Study 1	CVT is calculated from R-R intervals in electrocardiogram and measured on a validated linear vagal scale, where 0 represents full atropinisation. The investigators will continuously measure CVT during the 15-min baseline period, 30-min meal period, 15-min intervention period, and 3-h postprandial period.	from baseline to 3-hour postprandial period.
Primary	Comparison of changes in Meal-induced discomfort scores between healthy volunteers and rumination patients in Study 1	This score consists of 3 visual analog scales (VAS) of the level of nausea, fullness and epigastric discomfort. Each scale is graded from 0 to 5, where score 0 represents no perception and score 5 represents an extremely uncomfortable sensation. A Total score can vary between 0 and 15.	baseline, every 5 minutes during the 30-min meal period, every 30 minutes during the 3-hour postprandial period
Primary	Comparison of changes in the number of rumination episodes between Diaphragmatic breathing group and Deep slow breathing group in Study 2	Subjects will count the number of rumination episodes during 1-hour postprandial period in the laboratory.	from baseline to after the 4-week intervention period
Secondary	Comparison of changes in cardiac vagal tone (CVT) calculated from R-R intervals in electrocardiogram among 3 respiratory exercises in Study 1	CVT is calculated from R-R intervals in electrocardiogram and measured on a validated linear vagal scale, where 0 represents full atropinisation. The investigators will continuously measure CVT during the 15-min baseline period, 30-min meal period, 15-min intervention period, and 3-h postprandial period.	from baseline to 3-hour postprandial period.
Secondary	Comparison of the number of rumination episodes among 3 respiratory exercises in rumination patients in Study 1	The subjects will count the number of rumination episodes the 15-min baseline period, 30-min meal period, 15-min intervention period, and the first 1-hour postprandial period.	Baseline, meal period, 15-min intervention period, and first 1-hour postprandial period
Secondary	Comparison of Treatment Evaluation scores in 2 groups in Study 2	The subjects will rate the perception of their complaints compared to the pre-treatment period from -3 to +3: -3 totally unbearable, -2 much worse, -1 slightly worse, 0 no change, +1 slightly better, +2 much better, and +3 totally resolved).	Baseline and every week during the 4-week intervention period
Secondary	Comparison of changes in Meal-induced discomfort scores among 3 respiratory exercises in Study 1	This score consists of 3 visual analog scales (VAS) of the level of nausea, fullness and epigastric discomfort. Each scale is graded from 0 to 5, where score 0 represents no perception and score 5 represents an extremely uncomfortable sensation. Total scores can vary between 0 and 15.	baseline, every 5 minutes during the 30-min meal period, every 30 minutes during the 3-hour postprandial period