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Intranasal Challenge of Healthy Adults With Respiratory Syncytial Virus (RSV)

RSV Infection Clinical Trial

Official title:
A Phase 1 Randomized, Placebo-controlled, Double-blind Study to Evaluate the Safety and Efficacy of MEDI-557 in Healthy Adults Intranasally Challenged With Respiratory Syncytial Virus (RSV)

Clinical Trial Summary

The primary objective is to evaluate the suitability of the challenge model in measuring the efficacy of MEDI-557 compared to placebo in healthy adult participants for the reduction in the incidence of RSV through 12 days post-RSV challenge with the RSV Memphis-37 strain.

Clinical Trial Description

This is designed to be a double-blind, placebo-controlled, randomized study. Approximately 30 participants will be randomized, dosed and followed. Participants will be randomly assigned to receive a single intravenous (IV) dose of MEDI-557 or placebo. Participants will be inoculated with RSV-A. Participants will be followed for efficacy for 12 days post-RSV challenge. Safety follow-up will be approximately 12 months from randomization. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01475305
Study type Interventional
Source MedImmune LLC
Contact
Status Terminated
Phase Phase 1
Start date October 20, 2011
Completion date December 13, 2012
View Details
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