Bronchiolitis Clinical Trial
Official title:
A Prospective, Pilot Study Measuring Exhaled Nitric Oxide Levels in Infants and Young Children Admitted to the Hospital for Respiratory Syncytial Virus (RSV) or Other Viral Lower Respiratory Tract Infections
The fraction of exhaled nitric oxide (feNO) in expired air is a reliable measure of airway
inflammation. Some research experiments have demonstrated stimulation of nitric oxide
production in respiratory epithelial cells infected with RSV.
The principal aims are to determine if the fraction of exhaled nitric oxide (feNO) is
elevated in hospitalized pediatric patients with viral lower respiratory illness and to
determine if there is a difference in feNO level between RSV and non-RSV infection.
NO may play a role in the association between RSV, airway reactivity, and airway
inflammation.
This is a prospective, pilot study that will noninvasively measure feNO in children 0-4
years of age admitted to Winthrop University Hospital, as well as controls (children in the
same age range without respiratory conditions and who are well enough to perform the test).
Hospitalized children will be tested for RSV (enzyme immunoassay (EIA) & DFA) and via direct
fluorescent antigen technique (DFA) for influenza A & B, parainfluenza, human
metapneumovirus and adenovirus.
Method of feNO measurement will utilize the offline options for preschool children & infants
appropriate for age as described in the 2005 Joint Statement of the American Thoracic
Society & the European Respiratory Society when discussing tidal breathing techniques with
uncontrolled flow rate Offline exhaled air can be collected via a mouthpiece or a face mask
connected to a non-re-breathing valve that allows inspiration of NO-free air from an
NO-inert reservoir to avoid contamination by ambient NO. Exhaled breath samples are
collected into an NO-inert bag fitted with the expiratory port once a stable breathing
pattern is present.
The results of all 3 groups will be compared: control, RSV positive and RSV negative
samples.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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