Clinical Trial Details
— Status: Recruiting
Administrative data
| NCT number |
NCT05879003 |
| Other study ID # |
202012082RINB |
| Secondary ID |
|
| Status |
Recruiting |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
May 15, 2023 |
| Est. completion date |
July 2024 |
Study information
| Verified date |
May 2023 |
| Source |
National Taiwan University Hospital |
| Contact |
jiu jenq lin, PhD |
| Phone |
33668126 |
| Email |
jiujlin[@]ntu.edu.tw |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
The teres major and pectoralis major are adductors and may play a compensatory role for
deficit in rotator cuff function. The investigators aim to (1) determine the effects of
neuromuscular electrical stimulation (NMES) on the two adductors for the outcomes in
symptomatic rotator cuff tear subjects, and (2) evaluate the immediate effect of NMES on the
co-contraction of the adductors.Thirty symptomatic rotator cuff tear subjects will have NMES
on the two adductors. The investigators will measure the acromiohumeral distance by
ultrasonography and scapular kinematics during arm elevation with a three-dimensional motion
tracking system. Co-contractions will be calculated by surface electromyography.
Description:
Participants Based on the pilot study, a sample size of 30 patients is calculated to provide
80% power with an effect size of 0.5 (acromiohumeral distance difference = 0.9 mm with and
without NMES). Rotator cuff tear subjects will be recruited from the Department of Orthopedic
surgery or Department of Physical Medicine and Rehabilitation at National Taiwan University
Hospital (NTUH). All subjects will be provided written informed consent before inclusion in
the experiment. The study is approved by the NTUH Institutional Review Board.
Instrumentation Three-dimensional electromagnetic motion tracking system The Polhemus 3Space
FASTRAK® (Polhemus Inc., Colchester, VT, US), an electromagnetic motion analysis system with
MotionMonitor software (Innovative Sports Training, Inc., Chicago, IL, US), will be used to
track and collect three-dimensional scapular kinematics. Three sensors are attached to the
flat bony surface of the acromion and the sternum with adhesive tape, and to the distal
humerus between the lateral and medial epicondyles via Velcro straps with adhesive tape
(Figure 1). The other sensors are attached by a stylus to digitalize the 3-dimensional
positions on bony landmarks including the sternal notch, xiphoid process, C7 vertebrae, T8
vertebrae, T12 vertebrae, anterior and posterior glenohumeral joint, acromioclavicular joint,
root of the spine of the scapula, inferior angle of the scapula, and lateral and medial
epicondyles to build the shoulder complex model. Each receiver will be sampled at the rate of
120 updates/second divided by the number of sensors.
Ultrasonography (USG) measurements The BenQ T3300 Tablet Ultrasound System (BenQ Medical
Technology Corp., Taipei, Taiwan) with a L154BH linear array 4-15MHz broadband transducer
will be used for non-invasive evaluation of AHD in 3 actively abducted positions (at 0°, 60°,
and 90° of shoulder abduction). Real-time imaging will be performed with rapid B-mode
scanning to generate images with the following settings: gain, 66-68; dynamic range, 75;
persistence, 3; QScan, 4, for sharpness and smoothing; gray map, 3; Chroma 0; steer angle, 0;
and transducer, 5.5 MHz. The minimum measurement distance of this USG is 1 mm with error less
than ± 5%.
Neuromuscular Electrical Stimulation (NMES) The GM300TE COMBO NMES (Gemore Technology Co.,
Ltd., New Taipei City, Taiwan), a portable machine with dual controllable channels and a
manual switch, will be applied to the PM and TM. According to a previous study, muscle force
generation is modulated by stimulated frequency, pulse width, and intensity. It linearly
increases with stimulated amplitude and pulse duration. The electronics of the unit creates
the electrical impulses with an output frequency of 50 Hz and a pulse width of 300
microseconds. The synchronous (S) mode and asymmetrical rectangular wave-pulse are used
throughout the experiment. The amplitude is set as muscle motor-level contraction with
self-perception of maximal tolerable intensity. The time of tetanic stimulation is 7 seconds
with 20-second intervals between stimulations to avoid muscle fatigue. The two circular
electrodes are used on each adductor to minimize the stimulated interference with the nearby
muscles.
Surface electromyography (sEMG) Muscle activation will be collected at 1000 Hz/channel with
the resolution of a 16-bit A/D converter to 16-bit D/A analog converter (Model MP 150, Biopac
Systems Inc., Aero Camino Goleta, CA, USA). The system includes pairs of silver chloride
circular electrodes (diameter: 10 mm; Ludlow Company LP, Chicopee, MA) with an interelectrode
distance of 20 mm (center to center). The collected signals are amplified with a Grass AC/DC
amplifier (Model 15A12, Astro-Med Inc., West Warwick, RI, USA) with gain of 1000 dB, a
common-mode rejection ratio (CMRR) of 86 dB at 60 Hz, and a bandwidth (-3 dB) of 10 to 1000
Hz. Full bandwidth data (captured by the data acquisition and analysis systems software,
AcqKnowledge, Biopac, Aero Camino Goleta, CA) are reduced using a root mean square (RMS)
algorithm to produce envelopes with an effective sampling rate of 50 samples per second. The
mean of the three trials for each task are calculated for data analysis.
Force measurement system The force-sensitive measurement system (FlexiForce ELFTM, New Taipei
City, Taiwan) combines three single-point FlexiForce B201 sensors, one handle containing
USB-interface electronics, and Windows-compatible software. Three circular sensors (diameter
9.53 mm; thickness 0.203 mm) are able to detect the range of force as low (4.4-111 N), medium
(111-667 N) and high (667-4448 N) levels, respectively. This ensures that the various forces
during maximal voluntary isometric contraction can be measured by the appropriate sensor.
When the sensor detects the force, the software displays a histogram, curve graph, or number
of the force detected as the real-time bio-feedback. The sampling rate of the data collection
is set at 200 Hz.
Procedures Male subjects are asked to remove their shirts, and female subjects are asked to
wear an open-backed bathing suit throughout the experiment. The subjects are asked to do the
isometric abducted and adducted maximal isometric contraction test against the force sensors
on the customized iron-ring, respectively. The maximum force is simultaneously recorded as
the mean value during the isometric maximal isometric contraction tasks. Then acromiohumeral
distance is assessed by USG probe in 3 abducted positions (resting position, 60° and 90°)
with a custom-designed dynamic goniometer surrounding the distal part of the humerus. The USG
probe is applied parallelly to the humerus shaft and over the anterior aspect of the anterior
acromial margin. Three images are required for each position. Twenty-second intervals between
each image prevents muscle fatigue. Following the USD imaging, sEMG electrodes are placed on
the teres major and pectoralis major after the area is wiped clean with alcohol and scrubbed
to reduce the impedance of the skin. After placement of the electrodes, the subject hang
his/her arm in a neutral sitting posture with a force measurement sensor contacting the
wrist. Each subject performs five trials of the isometric abduction and adduction task
respectively at 60% of maximal force based on real-time force value feedback.
After that, the scapular kinematics during arm elevation are measured by FASTRAK in 5 trials.
First, a physical therapist attachs the sensors to build the local coordinate system for the
shoulder. Then the operator asks the subject to elevate the arm to ensure the angle was over
90° and to retract the scapula to confirm the axial direction of scapular internal/external
rotation displayed on the system. Second, the subjects are instructed to elevate the arm as
high as possible at a comfortable speed within 3 seconds and then slowly to lower the arm to
the starting position. An audible metronome set to 1 Hz is used as the cue during the
elevation task.
All subjects are asked to perform the same assessment with NMES. The order of NMES
application to the teres major or pectoralis major will be randomized. All the optimal NMES
attachments are confirmed with the recruiting activity by the motor point pen. Subsequently,
the maximal tolerable intensity is ensured and recorded in the three abducted positions. Then
the scapular kinematics during arm elevation and the acromiohumeral distance measurements in
specific arm positions are performed during NMES on one of the target adductors. Subjects are
asked to hold the specific arm position with NMES for at least 3 seconds in each trial during
the acromiohumeral distance measurement. In addition, the NMES is sustained for at least 7
seconds during the scapular kinematic tracking during arm elevation. After a 10-minute break
following the assessments, NMES on another adductor muscle is conducted. Following the NMES
stimulation, subjects performs the co-contraction assessment immediately. The muscle activity
data in both isometric abduction and adduction are immediately collected pre- and post-NMES.
Then the data of the scapular kinematics during arm elevation and the acromiohumeral distance
at resting position and at 60° and 90° of shoulder abduction are analyzed.
Statistical analysis Data will be analyzed in Statistical Package for the Social Sciences
(SPSS), version 22 (International Business Machines Corp., New York, USA). The Shapiro-Wilk
test is used to test for normality. With normal distribution, two-way ANOVAs (3 conditions x
3 positions for acromiohumeral distance measurements and 3 conditions x 6 positions of
scapular kinematics) will be used. The alpha level is set at 0.05 with two-tailed testing.
Without normal distribution, a nonparametric test (Friedman test) is used for data analysis.
Co-contraction ratios between baseline and immediately post-NMES are compared by t test or
Wilcoxon signed-rank test whether or not distribution is normal.
